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- W4254319150 abstract "Nonsense mutations are associated with a host of genetic disorders. The protein products encoded by genes containing these mutations are either truncated or completely missing. Recently, members of the aminoglycoside family of antibiotics have been found to induce the ribosome to read past these inappropriately inserted stop codons, albeit at extremely modest efficiencies. We report herein a strategy that enhances the production of functional proteins from the corresponding mutated genes." @default.
- W4254319150 created "2022-05-12" @default.
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- W4254319150 date "2004-04-15" @default.
- W4254319150 modified "2023-09-26" @default.
- W4254319150 title "Enhanced Production of Functional Proteins from Defective Genes" @default.
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- W4254319150 doi "https://doi.org/10.1021/ja0318939" @default.
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