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- W4254335023 abstract "Sudoxicam (SDX), a cyclooxygenase (COX) inhibitor, was a potential nonsteroidal anti‐inflammatory drug (NSAID), and withdrawn from further development due to the hepatotoxicity. In vitro, the compound underwent the oxidative thiazole‐open biotransformation, resulting in the formation of an acylthiourea and the subsequent hydroxylated metabolite. Additionally, the hydrolysis following the initial epoxide formation gave rise to a thiazole‐4,5‐dihydrodiol metabolite. The formation of secondary electrophilic metabolites such as S ‐oxides from the acylthiourea has been postulated to be associated with SDX‐induced hepatotoxicity. In vivo, the compound exhibited a long plasma half‐lives and small volume of distribution. Metabolic profiles in vivo appeared consistent among the experimental species and human, with the thiazole‐opened, the acylthiourea and thiohydrotoic acid, being the major metabolites." @default.
- W4254335023 created "2022-05-12" @default.
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- W4254335023 date "2013-10-13" @default.
- W4254335023 modified "2023-09-26" @default.
- W4254335023 title "Sudoxicam" @default.
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- W4254335023 doi "https://doi.org/10.1002/9781118541203.xen294" @default.
- W4254335023 hasPublicationYear "2013" @default.
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