FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254368960> ?p ?o ?g. }

• W4254368960 abstract "Workpackage5 of PharmaCog (E-ADNI) is a serial multicenter European study aimed to identify new biomarkers of disease progression in 147 patients with amnestic mild cognitive impairment (aMCI). Aim of this study is to investigate the longitudinal effects of amyloid and neurodegeneration on the white matter alterations in these patients. We report preliminary diffusion longitudinal data of 78 aMCI patients who underwent CSF collection at baseline and high resolution 3T MRI at baseline and after 12 months. Patients were enrolled in 13 memory clinics in Italy, France, Spain, Germany, Greece and The Netherlands. An atlas-based DTI analysis was performed to collect measures of fractional anisotropy (FA), mean, axial and radial diffusivity (MD, AD and RD, respectively) from corpus callosum, superior and inferior lateral fasciculi and corticospinal tracts (Jovicich et al., 2014). Patients were divided into 4 groups based on their Ab42 and Ptau CSF levels: biomarker negative (Ab-Ptau-neg), amyloid positive only (Ab-pos), neurodegeneration positive only (Ptau-pos) and amyloid-neurodegeneration positive (Ab-Ptau-pos). General linear model for repeated measures was performed considering amyloid and neurodegenerative status as independent variables, diffusion estimates as dependent variables and age and gender as covariates. Post-hoc Tukey's test was applied to compare the diffusion changes among the 4 groups. After one year, a similar trend of alterations was observed for all the diffusion metrics considered: Ab-Ptau-pos> Ptau-pos> Ab-pos> Ab-Ptau-neg. However, a significant interaction among time, Ab and PTau levels was reported only for RD (F(1,669)= 5.64, p= .02) and MD (F(1,669)= 7.01, p= .01). Ab-Ptau-pos showed higher increased in RD relative to aMCI without neurodegeneration (Ab-Ptau-neg and Ab-pos; Tukey's test, p<.050) and higher MD increase compared to Ab-pos (Tukey's test, p<.05). No significant FA and L1 alterations were observed. These preliminary data suggest that in aMCI patients i) amyloid pathology affects in white matter diffusion only when neurodegeneration coexists and ii) RD and MD seems more sensitive than FA and L1 to detect longitudinal diffusion changes. Longitudinal analysis is still ongoing. Pharmacog is funded by the EU-FP7 for the Innovative Medicine Initiative (grant 115009)." @default.
• W4254368960 created "2022-05-12" @default.
• W4254368960 creator A5007909621 @default.
• W4254368960 creator A5015389317 @default.
• W4254368960 creator A5019846852 @default.
• W4254368960 creator A5031923377 @default.
• W4254368960 creator A5035394476 @default.
• W4254368960 creator A5039782136 @default.
• W4254368960 creator A5042710338 @default.
• W4254368960 creator A5045793605 @default.
• W4254368960 creator A5051868596 @default.
• W4254368960 creator A5059866131 @default.
• W4254368960 creator A5062680763 @default.
• W4254368960 creator A5065251532 @default.
• W4254368960 creator A5067631090 @default.
• W4254368960 creator A5072555597 @default.
• W4254368960 creator A5079246880 @default.
• W4254368960 creator A5079806242 @default.
• W4254368960 creator A5080766962 @default.
• W4254368960 creator A5086914602 @default.
• W4254368960 date "2015-07-01" @default.
• W4254368960 modified "2023-10-09" @default.
• W4254368960 title "P4-087: Longitudinal white matter alterations of MCI patients in WP5 PharmaCog/E-ADNI study: Preliminary data" @default.
• W4254368960 doi "https://doi.org/10.1016/j.jalz.2015.06.1792" @default.
• W4254368960 hasPublicationYear "2015" @default.
• W4254368960 type Work @default.
• W4254368960 citedByCount "0" @default.
• W4254368960 crossrefType "journal-article" @default.
• W4254368960 hasAuthorship W4254368960A5007909621 @default.
• W4254368960 hasAuthorship W4254368960A5015389317 @default.
• W4254368960 hasAuthorship W4254368960A5019846852 @default.
• W4254368960 hasAuthorship W4254368960A5031923377 @default.
• W4254368960 hasAuthorship W4254368960A5035394476 @default.
• W4254368960 hasAuthorship W4254368960A5039782136 @default.
• W4254368960 hasAuthorship W4254368960A5042710338 @default.
• W4254368960 hasAuthorship W4254368960A5045793605 @default.
• W4254368960 hasAuthorship W4254368960A5051868596 @default.
• W4254368960 hasAuthorship W4254368960A5059866131 @default.
• W4254368960 hasAuthorship W4254368960A5062680763 @default.
• W4254368960 hasAuthorship W4254368960A5065251532 @default.
• W4254368960 hasAuthorship W4254368960A5067631090 @default.
• W4254368960 hasAuthorship W4254368960A5072555597 @default.
• W4254368960 hasAuthorship W4254368960A5079246880 @default.
• W4254368960 hasAuthorship W4254368960A5079806242 @default.
• W4254368960 hasAuthorship W4254368960A5080766962 @default.
• W4254368960 hasAuthorship W4254368960A5086914602 @default.
• W4254368960 hasConcept C126322002 @default.
• W4254368960 hasConcept C126838900 @default.
• W4254368960 hasConcept C142724271 @default.
• W4254368960 hasConcept C143409427 @default.
• W4254368960 hasConcept C143998085 @default.
• W4254368960 hasConcept C149550507 @default.
• W4254368960 hasConcept C15744967 @default.
• W4254368960 hasConcept C185592680 @default.
• W4254368960 hasConcept C2776925932 @default.
• W4254368960 hasConcept C2778183499 @default.
• W4254368960 hasConcept C2778373026 @default.
• W4254368960 hasConcept C2779134260 @default.
• W4254368960 hasConcept C2781192897 @default.
• W4254368960 hasConcept C2781197716 @default.
• W4254368960 hasConcept C502032728 @default.
• W4254368960 hasConcept C55493867 @default.
• W4254368960 hasConcept C67761136 @default.
• W4254368960 hasConcept C71924100 @default.
• W4254368960 hasConcept C89916169 @default.
• W4254368960 hasConcept C90924648 @default.
• W4254368960 hasConceptScore W4254368960C126322002 @default.
• W4254368960 hasConceptScore W4254368960C126838900 @default.
• W4254368960 hasConceptScore W4254368960C142724271 @default.
• W4254368960 hasConceptScore W4254368960C143409427 @default.
• W4254368960 hasConceptScore W4254368960C143998085 @default.
• W4254368960 hasConceptScore W4254368960C149550507 @default.
• W4254368960 hasConceptScore W4254368960C15744967 @default.
• W4254368960 hasConceptScore W4254368960C185592680 @default.
• W4254368960 hasConceptScore W4254368960C2776925932 @default.
• W4254368960 hasConceptScore W4254368960C2778183499 @default.
• W4254368960 hasConceptScore W4254368960C2778373026 @default.
• W4254368960 hasConceptScore W4254368960C2779134260 @default.
• W4254368960 hasConceptScore W4254368960C2781192897 @default.
• W4254368960 hasConceptScore W4254368960C2781197716 @default.
• W4254368960 hasConceptScore W4254368960C502032728 @default.
• W4254368960 hasConceptScore W4254368960C55493867 @default.
• W4254368960 hasConceptScore W4254368960C67761136 @default.
• W4254368960 hasConceptScore W4254368960C71924100 @default.
• W4254368960 hasConceptScore W4254368960C89916169 @default.
• W4254368960 hasConceptScore W4254368960C90924648 @default.
• W4254368960 hasIssue "7S_Part_17" @default.
• W4254368960 hasLocation W42543689601 @default.
• W4254368960 hasOpenAccess W4254368960 @default.
• W4254368960 hasPrimaryLocation W42543689601 @default.
• W4254368960 hasRelatedWork W1996104170 @default.
• W4254368960 hasRelatedWork W2000010321 @default.
• W4254368960 hasRelatedWork W2049444094 @default.
• W4254368960 hasRelatedWork W2080220338 @default.
• W4254368960 hasRelatedWork W2116365403 @default.
• W4254368960 hasRelatedWork W2387524778 @default.
• W4254368960 hasRelatedWork W2391066511 @default.
• W4254368960 hasRelatedWork W2765793352 @default.
• W4254368960 hasRelatedWork W4295021197 @default.
• W4254368960 hasRelatedWork W4380877411 @default.

• next