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- W4254371574 abstract "Letters and Corrections1 May 1989Neuropsychiatric HirsuitismSusan S. Braithwaite, MD, Mary Ann Emanuele, MD, Sonia Collins, MASusan S. Braithwaite, MDSearch for more papers by this author, Mary Ann Emanuele, MDSearch for more papers by this author, Sonia Collins, MASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-9-748 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In polycystic ovary syndrome (1) and in idiopathic hirsutism (2), the release of delta-5 steroids after administration of adrenocorticotropic hormone (ACTH) closely resembles an exaggeration of the pattern seen in normal adrenarche. In precocious adrenarche the levels of the delta-5 androgens dehydroepiandrosterone and dehydroepiandrosterone sulfate (DHEAS) are most clearly abnormal for age (3), and children who are affected have a high incidence of central nervous system dysfunction.In three adult women with neuropsychiatric disease who presented to us recently with hirsutism, the DHEAS concentrations at times equaled or exceeded 6.0 µg/mL (16.3 µM/L), a level reported by...References1. Barnes R and Rosenfield R. The polycystic ovary syndrome: pathogenesis and treatment. Ann Intern Med. 1989;110:386-99. LinkGoogle Scholar2. Rittmaster R and Loriaux D. Hirsutism. Ann Intern Med. 1987;106:95-107. LinkGoogle Scholar3. Korth-Schutz S, Levine L, and New M. Evidence for the adrenal source of androgens in precocious adrenarche. Acta Endocrinol. 1976;82:342-52. CrossrefMedlineGoogle Scholar4. Abraham G, Maroulis G, Buster J, Chang R, and Marshall J. Effect of dexamethasone on serum cortisol and androgen levels in hirsute patients. Obstet Gynecol. 1976;47:395-402. MedlineGoogle Scholar5. Wajchenberg B, Achando S, and Okada H. Determination of the source(s) of androgen overproduction in hirsutism associated with polycystic ovary syndrome by simultaneous adrenal and ovarian venous catheterization. Comparison with the dexamethasone suppression test. J Clin Endocrinol Metab. 1986;63:1204-10. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Susan S. Braithwaite, MD; Mary Ann Emanuele, MD; Sonia Collins, MAAffiliations: Loyola University Stritch School of Medicine Maywood, IL 60153 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReaders' ForumDrug-Induced Hypertrichosis: Case Report and Review of the LiteratureCorrection: Frequency Finding in Letter 1 May 1989Volume 110, Issue 9Page: 748-749KeywordsAdrenocorticotropic hormoneAndrogensAttentionCentral nervous systemChildrenDehydroepiandrosteronePolycystic ovary syndromeSteroidsSulfates ePublished: 1 December 2008 Issue Published: 1 May 1989 PDF downloadLoading ..." @default.
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