Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254373514> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4254373514 endingPage "418" @default.
- W4254373514 startingPage "409" @default.
- W4254373514 abstract "Delirium is a serious postoperative condition for which few pharmacologic prevention trials have been conducted. The authors tested the efficacy of perioperative olanzapine administration to prevent postoperative delirium in elderly patients after jointreplacement surgery. The authors conducted a randomized, double-blind, placebocontrolled, prophylaxis trial at an orthopedic teaching hospital, enrolling 495 elderly patients age ≥65 years, who were undergoing elective knee- or hip-replacement surgery; 400 patients received either 5 mg of orally-disintegrating olanzapine or placebo just before and after surgery. The primary efficacy outcome was the incidence of (DSM-III-R) delirium. The incidence of delirium was significantly lower in the olanzapine group than in the placebo group; this held true for both knee- and hip-replacement surgery. However, delirium lasted longer and was more severe in the olanzapine group. Advanced age, a high level of medical comorbidity, an abnormal albumin level, and having knee-replacement surgery were independent risk factors for postoperative delirium (Clinicaltrials.gov Identifier: NCT000699946). Administration of 10 mg of oral olanzapine perioperatively, versus placebo, was associated with a significantly lower incidence of delirium. These findings suggest that olanzapine prophylaxis of postoperative delirium may be an effective strategy." @default.
- W4254373514 created "2022-05-12" @default.
- W4254373514 creator A5000836426 @default.
- W4254373514 creator A5012163000 @default.
- W4254373514 creator A5017084079 @default.
- W4254373514 creator A5019884646 @default.
- W4254373514 creator A5029864990 @default.
- W4254373514 creator A5034851985 @default.
- W4254373514 creator A5042250149 @default.
- W4254373514 creator A5042484058 @default.
- W4254373514 creator A5049478716 @default.
- W4254373514 creator A5053260470 @default.
- W4254373514 creator A5069835598 @default.
- W4254373514 creator A5080921373 @default.
- W4254373514 date "2010-09-01" @default.
- W4254373514 modified "2023-09-29" @default.
- W4254373514 title "Administration of Olanzapine to Prevent Postoperative Delirium in Elderly Joint-Replacement Patients: A Randomized, Controlled Trial" @default.
- W4254373514 doi "https://doi.org/10.1176/appi.psy.51.5.409" @default.
- W4254373514 hasPublicationYear "2010" @default.
- W4254373514 type Work @default.
- W4254373514 citedByCount "10" @default.
- W4254373514 countsByYear W42543735142017 @default.
- W4254373514 countsByYear W42543735142018 @default.
- W4254373514 countsByYear W42543735142019 @default.
- W4254373514 countsByYear W42543735142020 @default.
- W4254373514 countsByYear W42543735142022 @default.
- W4254373514 crossrefType "journal-article" @default.
- W4254373514 hasAuthorship W4254373514A5000836426 @default.
- W4254373514 hasAuthorship W4254373514A5012163000 @default.
- W4254373514 hasAuthorship W4254373514A5017084079 @default.
- W4254373514 hasAuthorship W4254373514A5019884646 @default.
- W4254373514 hasAuthorship W4254373514A5029864990 @default.
- W4254373514 hasAuthorship W4254373514A5034851985 @default.
- W4254373514 hasAuthorship W4254373514A5042250149 @default.
- W4254373514 hasAuthorship W4254373514A5042484058 @default.
- W4254373514 hasAuthorship W4254373514A5049478716 @default.
- W4254373514 hasAuthorship W4254373514A5053260470 @default.
- W4254373514 hasAuthorship W4254373514A5069835598 @default.
- W4254373514 hasAuthorship W4254373514A5080921373 @default.
- W4254373514 hasBestOaLocation W42543735141 @default.
- W4254373514 hasConcept C118552586 @default.
- W4254373514 hasConcept C120665830 @default.
- W4254373514 hasConcept C121332964 @default.
- W4254373514 hasConcept C141071460 @default.
- W4254373514 hasConcept C142724271 @default.
- W4254373514 hasConcept C168563851 @default.
- W4254373514 hasConcept C204787440 @default.
- W4254373514 hasConcept C27081682 @default.
- W4254373514 hasConcept C2776412080 @default.
- W4254373514 hasConcept C2776619155 @default.
- W4254373514 hasConcept C2778336525 @default.
- W4254373514 hasConcept C2779753318 @default.
- W4254373514 hasConcept C2992051495 @default.
- W4254373514 hasConcept C31174226 @default.
- W4254373514 hasConcept C42219234 @default.
- W4254373514 hasConcept C61511704 @default.
- W4254373514 hasConcept C71924100 @default.
- W4254373514 hasConceptScore W4254373514C118552586 @default.
- W4254373514 hasConceptScore W4254373514C120665830 @default.
- W4254373514 hasConceptScore W4254373514C121332964 @default.
- W4254373514 hasConceptScore W4254373514C141071460 @default.
- W4254373514 hasConceptScore W4254373514C142724271 @default.
- W4254373514 hasConceptScore W4254373514C168563851 @default.
- W4254373514 hasConceptScore W4254373514C204787440 @default.
- W4254373514 hasConceptScore W4254373514C27081682 @default.
- W4254373514 hasConceptScore W4254373514C2776412080 @default.
- W4254373514 hasConceptScore W4254373514C2776619155 @default.
- W4254373514 hasConceptScore W4254373514C2778336525 @default.
- W4254373514 hasConceptScore W4254373514C2779753318 @default.
- W4254373514 hasConceptScore W4254373514C2992051495 @default.
- W4254373514 hasConceptScore W4254373514C31174226 @default.
- W4254373514 hasConceptScore W4254373514C42219234 @default.
- W4254373514 hasConceptScore W4254373514C61511704 @default.
- W4254373514 hasConceptScore W4254373514C71924100 @default.
- W4254373514 hasIssue "5" @default.
- W4254373514 hasLocation W42543735141 @default.
- W4254373514 hasOpenAccess W4254373514 @default.
- W4254373514 hasPrimaryLocation W42543735141 @default.
- W4254373514 hasRelatedWork W2164961763 @default.
- W4254373514 hasRelatedWork W2217365523 @default.
- W4254373514 hasRelatedWork W2326581551 @default.
- W4254373514 hasRelatedWork W2409856569 @default.
- W4254373514 hasRelatedWork W2464246482 @default.
- W4254373514 hasRelatedWork W2981939960 @default.
- W4254373514 hasRelatedWork W4225292301 @default.
- W4254373514 hasRelatedWork W4225328311 @default.
- W4254373514 hasRelatedWork W4254373514 @default.
- W4254373514 hasRelatedWork W3031686653 @default.
- W4254373514 hasVolume "51" @default.
- W4254373514 isParatext "false" @default.
- W4254373514 isRetracted "false" @default.
- W4254373514 workType "article" @default.