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- W4254413216 abstract "Background & Aims: Inducible histamine and histamine H2-receptors have been suggested to be involved in innate immune response. Methods: We examined a functional role of inducible histamine in the protection against hepatic injury and lethality in Propionibacterium acnes-primed and lipopolysaccharide-induced hepatitis, using histidine decarboxylase knockout and H2-receptor knockout mice. Results: Lipopolysaccharide challenge after Propionibacterium acnes priming increased histidine decarboxylase activity in the liver of wild-type mice, associated with a marked elevation of histamine turnover. Histidine decarboxylase-like immunoreactivity was observed in CD68-positive Kupffer cells/macrophages. Treatment of wild-type mice with famotidine or ranitidine but not d-chlorpheniramine augmented hepatic injury and inhibited the survival rate significantly. The same dose of Propionibacterium acnes and lipopolysaccharide induced severe hepatitis and high lethality in histidine decarboxylase knockout and H2-receptor knockout mice; the former were rescued by the subcutaneous injection of histamine. Immunohistochemical study supported the protective role of histamine against the apoptosis of hepatocytes. Histamine suppressed the expression of IL-18 and tumor necrosis factor α in the liver, leading to the reduced plasma levels of cytokines including IL-18, TNF-α, IL-12, IFN-γ, and IL-6. Conclusions: These findings as a whole indicated that endogenously produced histamine in Kupffer cells/macrophages plays a very important role in preventing excessive innate immune response in endotoxin-induced fulminant hepatitis through the stimulation of H2-receptors." @default.
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- W4254413216 date "1991-05-01" @default.
- W4254413216 modified "2023-10-16" @default.
- W4254413216 title "Biochemical pharmacology of the atypical neuroleptic remoxipride" @default.
- W4254413216 doi "https://doi.org/10.1016/0920-9964(91)90214-c" @default.
- W4254413216 hasPublicationYear "1991" @default.
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