FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254446649> ?p ?o ?g. }

• W4254446649 endingPage "S475" @default.
• W4254446649 startingPage "S475" @default.
• W4254446649 abstract "To determine the efficacy and toxicity profile of salvage brachytherapy for locally recurrent prostate cancer after definitive external beam radiation therapy. Fewer than 100 such cases in the post-PSA era have been described in the literature. Twelve consecutive patients received salvage brachytherapy for locally recurrent prostate cancer after prior definitive external beam radiation therapy that delivered between 70-74 Gy. Histologic confirmation of local prostate cancer recurrence was required as was absence of radiographic evidence of distant metastases. A total of three months of LHRH agonist therapy was administered prior to ultrasound-guided 125I or 103Pd permanent interstitial brachytherapy and prescribed doses were 75% of standard doses for monotherapy brachytherapy. Subsequent biochemical recurrence was defined by the ASTRO consensus definition. Pre- and post-implant IPSS urinary symptom scores were recorded and serial post-implant PSA levels were obtained. With a median follow-up of 34 months (12–52) 10 of the 12 patients remain free of biochemical recurrence. Prior to the original external beam radiation therapy, the median presenting PSA and Gleason scores were 3.85 (1.8–11.5) and 6 (4–7), respectively. After external beam therapy, the median PSA nadir was 0.7, the median time to PSA recurrence was 63 months (24.5–102), and the median PSA doubling time was 184 days (145–857). After salvage brachytherapy, two biochemical recurrences were observed at 18 and 52 months, respectively. At one month post-implant, the median IPSS score increase was 10.5 (3–25), but this declined to 6 (1–16) by last follow-up and in general continued to improve with time. One patient experienced long-term urinary incontinence secondary to urethral scar formation, but there were no documented procedure-related rectal toxicities in any patient. With a median follow-up of nearly three years, salvage brachytherapy reestablished biochemical control in a group of originally favorable risk patients failing external beam radiation therapy. Importantly, rectal toxicities were absent and post-brachytherapy, urinary symptom scores, while initially elevated, continued to improve with time. Finally, the frequency of urinary incontinence was very low, comparing favorably with rates reported after salvage prostatectomy" @default.
• W4254446649 created "2022-05-12" @default.
• W4254446649 creator A5004593069 @default.
• W4254446649 creator A5007246333 @default.
• W4254446649 creator A5015241179 @default.
• W4254446649 creator A5051263378 @default.
• W4254446649 date "2004-09-01" @default.
• W4254446649 modified "2023-09-24" @default.
• W4254446649 title "Salvage brachytherapy for locally recurrent prostate cancer after definitive external beam radiation therapy" @default.
• W4254446649 doi "https://doi.org/10.1016/s0360-3016(04)01699-2" @default.
• W4254446649 hasPublicationYear "2004" @default.
• W4254446649 type Work @default.
• W4254446649 citedByCount "0" @default.
• W4254446649 crossrefType "journal-article" @default.
• W4254446649 hasAuthorship W4254446649A5004593069 @default.
• W4254446649 hasAuthorship W4254446649A5007246333 @default.
• W4254446649 hasAuthorship W4254446649A5015241179 @default.
• W4254446649 hasAuthorship W4254446649A5051263378 @default.
• W4254446649 hasConcept C121608353 @default.
• W4254446649 hasConcept C126322002 @default.
• W4254446649 hasConcept C126894567 @default.
• W4254446649 hasConcept C141071460 @default.
• W4254446649 hasConcept C2775908122 @default.
• W4254446649 hasConcept C2776694085 @default.
• W4254446649 hasConcept C2777008409 @default.
• W4254446649 hasConcept C2777416452 @default.
• W4254446649 hasConcept C2779466945 @default.
• W4254446649 hasConcept C2780192828 @default.
• W4254446649 hasConcept C2780775027 @default.
• W4254446649 hasConcept C2781411149 @default.
• W4254446649 hasConcept C2989005 @default.
• W4254446649 hasConcept C3020003399 @default.
• W4254446649 hasConcept C509974204 @default.
• W4254446649 hasConcept C71924100 @default.
• W4254446649 hasConceptScore W4254446649C121608353 @default.
• W4254446649 hasConceptScore W4254446649C126322002 @default.
• W4254446649 hasConceptScore W4254446649C126894567 @default.
• W4254446649 hasConceptScore W4254446649C141071460 @default.
• W4254446649 hasConceptScore W4254446649C2775908122 @default.
• W4254446649 hasConceptScore W4254446649C2776694085 @default.
• W4254446649 hasConceptScore W4254446649C2777008409 @default.
• W4254446649 hasConceptScore W4254446649C2777416452 @default.
• W4254446649 hasConceptScore W4254446649C2779466945 @default.
• W4254446649 hasConceptScore W4254446649C2780192828 @default.
• W4254446649 hasConceptScore W4254446649C2780775027 @default.
• W4254446649 hasConceptScore W4254446649C2781411149 @default.
• W4254446649 hasConceptScore W4254446649C2989005 @default.
• W4254446649 hasConceptScore W4254446649C3020003399 @default.
• W4254446649 hasConceptScore W4254446649C509974204 @default.
• W4254446649 hasConceptScore W4254446649C71924100 @default.
• W4254446649 hasLocation W42544466491 @default.
• W4254446649 hasOpenAccess W4254446649 @default.
• W4254446649 hasPrimaryLocation W42544466491 @default.
• W4254446649 hasRelatedWork W2013680501 @default.
• W4254446649 hasRelatedWork W2069598091 @default.
• W4254446649 hasRelatedWork W2138863125 @default.
• W4254446649 hasRelatedWork W2529939135 @default.
• W4254446649 hasRelatedWork W2589433410 @default.
• W4254446649 hasRelatedWork W2760542346 @default.
• W4254446649 hasRelatedWork W2913771305 @default.
• W4254446649 hasRelatedWork W4242491759 @default.
• W4254446649 hasRelatedWork W4293049207 @default.
• W4254446649 hasRelatedWork W71823916 @default.
• W4254446649 hasVolume "60" @default.
• W4254446649 isParatext "false" @default.
• W4254446649 isRetracted "false" @default.
• W4254446649 workType "article" @default.