Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254450160> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4254450160 endingPage "A109" @default.
- W4254450160 startingPage "A109.1" @default.
- W4254450160 abstract "<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic inflammatory joint disease which is associated with an increased cardiovascular (CV) risk. It is still unknown to what extent this is due to CV risk factors or the underlying inflammatory process in RA. With the advent of effective anti-inflammatory and cardioprotective treatment, this risk might be mitigated or even reduced. <h3>Objectives</h3> The present study compared changes in CV risk factors, RA-related factors and medication use over time in RA-patients who did and did not develop CV disease during follow-up. <h3>Methods</h3> Starting from 2000-2001, 10-year incidence rate of CV disease, CV risk factors, RA-related factors and medication use were assessed in a prospective cohort of 353 RA patients at baseline, at 3-years and at 10-years of follow-up. Associations between the changes in RA related factors and development of CV disease were assessed using generalized estimating equation (GEE) analyses, while changes in all variables were assessed with general linear models (GLM). <h3>Results</h3> After 10 years, there were 58 CV events over 2361 patient years of follow-up, incidence rate (IR) of 25.3/1.000 patientyears. This was similar to the IR at 3-years of follow-up: 22.8/1.000 patientyears. GLM analyses showed that use of antihypertensives, statins, TNF inhibitors and general CV risk increased significantly over time in the entire population, while RA related factors improved significantly (see enclosed figure). GEE analyses showed that increased use of TNF inhibitors was positively associated with less incident CV disease. <h3>Image/graph</h3> <h3>Conclusions</h3> The risk of incident CV disease persists in patients with RA despite the advent of effective anti-inflammatory therapies and increased use of cardioprotective medication in recent years. Patients who used TNF inhibitors and, more indirectly, had a reduction in inflammation or disease activity, were less at risk of developing a CV disease. General CV risk and use of cardioprotective medications did not attenuate this association. <h3>Disclosure of Interest</h3> None Declared" @default.
- W4254450160 created "2022-05-12" @default.
- W4254450160 creator A5004330868 @default.
- W4254450160 creator A5038173763 @default.
- W4254450160 creator A5039265980 @default.
- W4254450160 creator A5042768514 @default.
- W4254450160 creator A5043315520 @default.
- W4254450160 creator A5052934473 @default.
- W4254450160 creator A5086687326 @default.
- W4254450160 date "2013-06-01" @default.
- W4254450160 modified "2023-10-14" @default.
- W4254450160 title "OP0166 Sustained Development of Cardiovascular Disease in Rheumatoid Arthritis Despite Cardioprotective Treatment: The 10-Year Prospective Carre-Study" @default.
- W4254450160 doi "https://doi.org/10.1136/annrheumdis-2013-eular.371" @default.
- W4254450160 hasPublicationYear "2013" @default.
- W4254450160 type Work @default.
- W4254450160 citedByCount "0" @default.
- W4254450160 crossrefType "journal-article" @default.
- W4254450160 hasAuthorship W4254450160A5004330868 @default.
- W4254450160 hasAuthorship W4254450160A5038173763 @default.
- W4254450160 hasAuthorship W4254450160A5039265980 @default.
- W4254450160 hasAuthorship W4254450160A5042768514 @default.
- W4254450160 hasAuthorship W4254450160A5043315520 @default.
- W4254450160 hasAuthorship W4254450160A5052934473 @default.
- W4254450160 hasAuthorship W4254450160A5086687326 @default.
- W4254450160 hasConcept C105795698 @default.
- W4254450160 hasConcept C120665830 @default.
- W4254450160 hasConcept C121332964 @default.
- W4254450160 hasConcept C126322002 @default.
- W4254450160 hasConcept C188816634 @default.
- W4254450160 hasConcept C201903717 @default.
- W4254450160 hasConcept C27403532 @default.
- W4254450160 hasConcept C2777077863 @default.
- W4254450160 hasConcept C2777575956 @default.
- W4254450160 hasConcept C2779134260 @default.
- W4254450160 hasConcept C2908647359 @default.
- W4254450160 hasConcept C33923547 @default.
- W4254450160 hasConcept C50440223 @default.
- W4254450160 hasConcept C53084192 @default.
- W4254450160 hasConcept C61511704 @default.
- W4254450160 hasConcept C71924100 @default.
- W4254450160 hasConcept C72563966 @default.
- W4254450160 hasConcept C99454951 @default.
- W4254450160 hasConceptScore W4254450160C105795698 @default.
- W4254450160 hasConceptScore W4254450160C120665830 @default.
- W4254450160 hasConceptScore W4254450160C121332964 @default.
- W4254450160 hasConceptScore W4254450160C126322002 @default.
- W4254450160 hasConceptScore W4254450160C188816634 @default.
- W4254450160 hasConceptScore W4254450160C201903717 @default.
- W4254450160 hasConceptScore W4254450160C27403532 @default.
- W4254450160 hasConceptScore W4254450160C2777077863 @default.
- W4254450160 hasConceptScore W4254450160C2777575956 @default.
- W4254450160 hasConceptScore W4254450160C2779134260 @default.
- W4254450160 hasConceptScore W4254450160C2908647359 @default.
- W4254450160 hasConceptScore W4254450160C33923547 @default.
- W4254450160 hasConceptScore W4254450160C50440223 @default.
- W4254450160 hasConceptScore W4254450160C53084192 @default.
- W4254450160 hasConceptScore W4254450160C61511704 @default.
- W4254450160 hasConceptScore W4254450160C71924100 @default.
- W4254450160 hasConceptScore W4254450160C72563966 @default.
- W4254450160 hasConceptScore W4254450160C99454951 @default.
- W4254450160 hasIssue "Suppl 3" @default.
- W4254450160 hasLocation W42544501601 @default.
- W4254450160 hasOpenAccess W4254450160 @default.
- W4254450160 hasPrimaryLocation W42544501601 @default.
- W4254450160 hasRelatedWork W2056422115 @default.
- W4254450160 hasRelatedWork W2074121801 @default.
- W4254450160 hasRelatedWork W2080363649 @default.
- W4254450160 hasRelatedWork W2084880627 @default.
- W4254450160 hasRelatedWork W2137777248 @default.
- W4254450160 hasRelatedWork W2145191148 @default.
- W4254450160 hasRelatedWork W2472729884 @default.
- W4254450160 hasRelatedWork W2626569763 @default.
- W4254450160 hasRelatedWork W2894728770 @default.
- W4254450160 hasRelatedWork W4297990050 @default.
- W4254450160 hasVolume "72" @default.
- W4254450160 isParatext "false" @default.
- W4254450160 isRetracted "false" @default.
- W4254450160 workType "article" @default.