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- W4254492989 abstract "Background: Defects of the extrahepatic bile duct are a major issue in hepatobiliary surgery. In most cases, a bilioenteric anastomosis is the only treatment option. This procedure goes along with several disadvantages like recurrent cholangitis. Aim of this prospective animal study was the evaluation of biocellulosis as a replacement material for extrahepatic bile duct defects. Methods: In male pigs, three centimeter of the extrahepatic bile duct were resected. In the resulting defect a corresponding tube of biocellulosis was interposed. The tube was biotechnologically synthesized by Gluconacetobacter xylinus. Furthermore, a commercially available biliary stent was implanted and fixed at the tube. 12 weeks after the implantation, the animals were sacrificed. In two pigs, stent and tube were removed in a second surgical procedure 12 weeks after implantation and the euthanasia was done four weeks thereafter. Results: 12 weeks after the implantation, the bile duct was completely regenerated. Within the group, where the tube and the stent were removed, we found a completely stable, intact extrahepatic bile duct. Histologically, there was the typical bile structure with a biliary epithelium as the inner layer. Conclusion: The interposition of a biocellulosis tube induces the regeneration of the extrahepatic bile duct. The tube itself can be removed easily after 12 weeks. Therefore, no foreign substance remains in situ. Hepatobiliary application fields are liver transplantation, injuries after cholecystectomy and biliary tumors." @default.
- W4254492989 created "2022-05-12" @default.
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- W4254492989 date "2019-01-01" @default.
- W4254492989 modified "2023-10-14" @default.
- W4254492989 title "Biocellulosis induces regeneration of the extrahepatic bile duct" @default.
- W4254492989 doi "https://doi.org/10.1016/j.hpb.2019.10.073" @default.
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