Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254527889> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4254527889 endingPage "111" @default.
- W4254527889 startingPage "111" @default.
- W4254527889 abstract "The viral envelope glycoprotein D from bovine herpesviruses 1 and 5 (BoHV-1 and -5), two important pathogens of cattle, is a major component of the virion and plays a critical role in the pathogenesis of herpesviruses. Glycoprotein D is essential for virus penetration into permissive cells and thus is a major target for virus neutralizing antibodies during infection. In view of its role in the induction of protective immunity, gD has been tested in new vaccine development strategies against both viruses. Subunit, DNA and vectored vaccine candidates have been developed using this glycoprotein as the primary antigen, demonstrating that gD has the capacity to induce robust virus neutralizing antibodies and strong cell-mediated immune responses, as well as protection from clinical symptoms, in target species. This review highlights the structural and functional characteristics of BoHV-1, BoHV-5 and where appropriate, Human herpesvirus gD, as well as its role in viral entry and interactions with host cell receptors. Furthermore, the interactions of gD with the host immune system are discussed. Finally, the application of this glycoprotein in new vaccine design is reviewed, taking its structural and functional characteristics into consideration." @default.
- W4254527889 created "2022-05-12" @default.
- W4254527889 creator A5033620399 @default.
- W4254527889 creator A5033660680 @default.
- W4254527889 creator A5084967847 @default.
- W4254527889 date "2014-01-01" @default.
- W4254527889 modified "2023-09-26" @default.
- W4254527889 title "Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology" @default.
- W4254527889 doi "https://doi.org/10.1186/preaccept-1954748051348215" @default.
- W4254527889 hasPublicationYear "2014" @default.
- W4254527889 type Work @default.
- W4254527889 citedByCount "0" @default.
- W4254527889 crossrefType "journal-article" @default.
- W4254527889 hasAuthorship W4254527889A5033620399 @default.
- W4254527889 hasAuthorship W4254527889A5033660680 @default.
- W4254527889 hasAuthorship W4254527889A5084967847 @default.
- W4254527889 hasBestOaLocation W42545278891 @default.
- W4254527889 hasConcept C108625454 @default.
- W4254527889 hasConcept C132787861 @default.
- W4254527889 hasConcept C140704245 @default.
- W4254527889 hasConcept C159047783 @default.
- W4254527889 hasConcept C159654299 @default.
- W4254527889 hasConcept C203014093 @default.
- W4254527889 hasConcept C2522874641 @default.
- W4254527889 hasConcept C2776409557 @default.
- W4254527889 hasConcept C2777594917 @default.
- W4254527889 hasConcept C2779261636 @default.
- W4254527889 hasConcept C2779341262 @default.
- W4254527889 hasConcept C2780727368 @default.
- W4254527889 hasConcept C54355233 @default.
- W4254527889 hasConcept C58475186 @default.
- W4254527889 hasConcept C86803240 @default.
- W4254527889 hasConcept C8891405 @default.
- W4254527889 hasConcept C97380033 @default.
- W4254527889 hasConceptScore W4254527889C108625454 @default.
- W4254527889 hasConceptScore W4254527889C132787861 @default.
- W4254527889 hasConceptScore W4254527889C140704245 @default.
- W4254527889 hasConceptScore W4254527889C159047783 @default.
- W4254527889 hasConceptScore W4254527889C159654299 @default.
- W4254527889 hasConceptScore W4254527889C203014093 @default.
- W4254527889 hasConceptScore W4254527889C2522874641 @default.
- W4254527889 hasConceptScore W4254527889C2776409557 @default.
- W4254527889 hasConceptScore W4254527889C2777594917 @default.
- W4254527889 hasConceptScore W4254527889C2779261636 @default.
- W4254527889 hasConceptScore W4254527889C2779341262 @default.
- W4254527889 hasConceptScore W4254527889C2780727368 @default.
- W4254527889 hasConceptScore W4254527889C54355233 @default.
- W4254527889 hasConceptScore W4254527889C58475186 @default.
- W4254527889 hasConceptScore W4254527889C86803240 @default.
- W4254527889 hasConceptScore W4254527889C8891405 @default.
- W4254527889 hasConceptScore W4254527889C97380033 @default.
- W4254527889 hasIssue "1" @default.
- W4254527889 hasLocation W42545278891 @default.
- W4254527889 hasLocation W42545278892 @default.
- W4254527889 hasLocation W42545278893 @default.
- W4254527889 hasLocation W42545278894 @default.
- W4254527889 hasOpenAccess W4254527889 @default.
- W4254527889 hasPrimaryLocation W42545278891 @default.
- W4254527889 hasRelatedWork W105198329 @default.
- W4254527889 hasRelatedWork W1561945694 @default.
- W4254527889 hasRelatedWork W2022359538 @default.
- W4254527889 hasRelatedWork W2025225785 @default.
- W4254527889 hasRelatedWork W206283373 @default.
- W4254527889 hasRelatedWork W2100800614 @default.
- W4254527889 hasRelatedWork W2106344766 @default.
- W4254527889 hasRelatedWork W2147439533 @default.
- W4254527889 hasRelatedWork W2982091154 @default.
- W4254527889 hasRelatedWork W4254527889 @default.
- W4254527889 hasVolume "45" @default.
- W4254527889 isParatext "false" @default.
- W4254527889 isRetracted "false" @default.
- W4254527889 workType "article" @default.