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- W4254528305 abstract "There is an increasing push to identify the neurobiology associated with Autism Spectrum Disorder (ASD) including via Magnetic Resonance Imaging (MRI). Much of the previous research, however, has used behavioral or intelligence score criteria to increase feasibility of such assessments, particularly in studies investigating the effects of intervention on the brain. Such restrictions, however, exclude a significant proportion of potential participants with ASD, potentially biasing the development of subtypes and treatments. To address the need for inclusive clinical trials that include neurobiological measures, this study investigated the feasibility of MRI scanning in a comprehensive, inclusive clinical trial for children (aged 3-12 years) with ASD. No adaptive functioning or IQ score criteria were required for enrollment into the trial. Of the 71 participants who consented to the MRI component of the protocol, 24 successfully completed the scan at baseline. At post-treatment, 22 participants returned, with 21 successful scan completions. This study illustrates the possibility of MRI inclusion in comprehensive clinical trials that include a number of measures for children with ASD and highlights limitations evident when MRI is not the focus of the trial." @default.
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- W4254528305 date "2020-02-14" @default.
- W4254528305 modified "2023-09-24" @default.
- W4254528305 title "The feasibility of Magnetic Resonance Imaging in a non-selective comprehensive clinical trial in pediatric Autism Spectrum Disorder" @default.
- W4254528305 doi "https://doi.org/10.31219/osf.io/br2je" @default.
- W4254528305 hasPublicationYear "2020" @default.
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