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- W4254579583 abstract "<p>A metabolomics profiling approach was conducted to identify diagnostic biomarkers of PD from sebum, a non-invasively available biofluid. In this study, we used liquid chromatography-mass spectrometry (LC-MS) to analyse 274 samples from participants (80 drug naïve PD, 138 medicated PD and 56 well matched control subjects) and detected metabolites that could predict PD phenotype. Partial least squares-discriminant analysis (PLS-DA) models based on this sebum metabolome had correct classification rates of 70.4% and 69.7% to distinguish between drug naïve PD and medicated PD from control, respectively. Variable importance in projection (VIP) scores indicate compounds with significance belonged to sphingolipid, triacylglycerol and fatty acid/ester lipid classes. Pathway enrichment analysis showed alterations in lipid metabolism and mitochondrial dysfunction <i>viz.</i> the carnitine shuttle, sphingolipid metabolism and arachidonic acid metabolism. This study unveiled novel diagnostic sebum-based biomarkers for PD, and provides insight towards our current understanding of the pathogenesis of PD.</p>" @default.
- W4254579583 created "2022-05-12" @default.
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- W4254579583 date "2020-01-17" @default.
- W4254579583 modified "2023-09-24" @default.
- W4254579583 title "Sebum: A Window into Dysregulation of Mitochondrial Metabolism in Parkinson’s Disease" @default.
- W4254579583 doi "https://doi.org/10.26434/chemrxiv.11603613.v1" @default.
- W4254579583 hasPublicationYear "2020" @default.
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