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• W4254752814 abstract "Neuropathic pain is very challenging to manage because of the heterogeneity of aetiologies, symptoms, and underlying mechanisms. Conventional oral therapies have been limited by negative factors such as systemic side effects, drug–drug interactions, slow onset of action, the need for titration, multiple daily dosing, as well as the potential risk of addiction, dependence, withdrawal symptoms, and abuse. Therefore new therapeutic perspectives are justified. New drugs that act on different therapeutic targets are currently in preclinical development or in their first phases of clinical development. In this review, focus will be directed specifically on new pharmacological treatments for neuropathic pain for which clinical data are already available, including older and known drugs with new data on their anti-neuropathic activity.El dolor neuropático es difícil de tratar debido a la heterogeneidad de causas, síntomas y mecanismos subyacentes. Los tratamientos orales convencionales se han visto limitados por factores negativos, como efectos secundarios sistémicos, interacciones farmacológicas, inicio de acción lento, necesidad de ajuste de la dosis, administración de múltiples dosis diarias, y posible riesgo de adicción, dependencia, síntomas de abstinencia y uso excesivo. Por tanto, se justifican nuevas perspectivas terapéuticas. Actualmente, se encuentran en desarrollo preclínico o en sus primeras fases de desarrollo clínico nuevos fármacos que actúan sobre diferentes dianas terapéuticas. En esta revisión nos centraremos expresamente en nuevos tratamientos farmacológicos para el dolor neuropático para los cuales ya se dispone de datos clínicos, incluyendo fármacos más antiguos y conocidos con nuevos datos sobre su actividad antineuropática." @default.
• W4254752814 created "2022-05-12" @default.
• W4254752814 creator A5079921967 @default.
• W4254752814 date "2018-07-01" @default.
• W4254752814 modified "2023-10-18" @default.
• W4254752814 title "Central sensitization syndrome: Towards the structuring of a multidisciplinary concept" @default.
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• W4254752814 doi "https://doi.org/10.1016/j.medcle.2018.05.026" @default.
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