Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254755521> ?p ?o ?g. }
- W4254755521 endingPage "4744" @default.
- W4254755521 startingPage "4724" @default.
- W4254755521 abstract "Randomized clinical trials are often designed to assess whether a test treatment prolongs survival relative to a control treatment. Increased patient heterogeneity, while desirable for generalizability of results, can weaken the ability of common statistical approaches to detect treatment differences, potentially hampering the regulatory approval of safe and efficacious therapies. A novel solution to this problem is proposed. A list of baseline covariates that have the potential to be prognostic for survival under either treatment is pre‐specified in the analysis plan. At the analysis stage, using all observed survival times but blinded to patient‐level treatment assignment, “noise” covariates are removed with elastic net Cox regression. The shortened covariate list is used by a conditional inference tree algorithm to segment the heterogeneous trial population into subpopulations of prognostically homogeneous patients (risk strata). After patient‐level treatment unblinding, a treatment comparison is done within each formed risk stratum and stratum‐level results are combined for overall statistical inference. The impressive power‐boosting performance of our proposed 5‐step stratified testing and amalgamation routine (5‐STAR), relative to that of the logrank test and other common approaches that do not leverage inherently structured patient heterogeneity, is illustrated using a hypothetical and two real datasets along with simulation results. Furthermore, the importance of reporting stratum‐level comparative treatment effects (time ratios from accelerated failure time model fits in conjunction with model averaging and, as needed, hazard ratios from Cox proportional hazard model fits) is highlighted as a potential enabler of personalized medicine. An R package is available at https://github.com/rmarceauwest/fiveSTAR ." @default.
- W4254755521 created "2022-05-12" @default.
- W4254755521 creator A5002793654 @default.
- W4254755521 creator A5020047598 @default.
- W4254755521 date "2020-09-20" @default.
- W4254755521 modified "2023-09-27" @default.
- W4254755521 title "Survival analysis using a <scp>5‐step</scp> stratified testing and amalgamation routine (5‐STAR) in randomized clinical trials" @default.
- W4254755521 cites W1520609538 @default.
- W4254755521 cites W1867182292 @default.
- W4254755521 cites W1963508587 @default.
- W4254755521 cites W1966714873 @default.
- W4254755521 cites W1991528069 @default.
- W4254755521 cites W1994672023 @default.
- W4254755521 cites W2006623746 @default.
- W4254755521 cites W2011284201 @default.
- W4254755521 cites W2012221146 @default.
- W4254755521 cites W2018697056 @default.
- W4254755521 cites W2031330193 @default.
- W4254755521 cites W2075546513 @default.
- W4254755521 cites W2101095383 @default.
- W4254755521 cites W2104347254 @default.
- W4254755521 cites W2106916900 @default.
- W4254755521 cites W2122825543 @default.
- W4254755521 cites W2123998733 @default.
- W4254755521 cites W2125296802 @default.
- W4254755521 cites W2129580325 @default.
- W4254755521 cites W2135046866 @default.
- W4254755521 cites W2137545466 @default.
- W4254755521 cites W2151981428 @default.
- W4254755521 cites W2187668060 @default.
- W4254755521 cites W2198093519 @default.
- W4254755521 cites W2328829411 @default.
- W4254755521 cites W2334058643 @default.
- W4254755521 cites W2345502178 @default.
- W4254755521 cites W2476265589 @default.
- W4254755521 cites W2513620822 @default.
- W4254755521 cites W2567564314 @default.
- W4254755521 cites W2590767873 @default.
- W4254755521 cites W2763265527 @default.
- W4254755521 cites W2804105316 @default.
- W4254755521 cites W2806446597 @default.
- W4254755521 cites W2899940828 @default.
- W4254755521 cites W2902218997 @default.
- W4254755521 cites W2943529586 @default.
- W4254755521 cites W2964064567 @default.
- W4254755521 cites W2968892514 @default.
- W4254755521 cites W2977606681 @default.
- W4254755521 cites W3099478002 @default.
- W4254755521 cites W3147894994 @default.
- W4254755521 cites W4230727657 @default.
- W4254755521 cites W4234698323 @default.
- W4254755521 doi "https://doi.org/10.1002/sim.8750" @default.
- W4254755521 hasPublicationYear "2020" @default.
- W4254755521 type Work @default.
- W4254755521 citedByCount "2" @default.
- W4254755521 countsByYear W42547555212021 @default.
- W4254755521 countsByYear W42547555212022 @default.
- W4254755521 crossrefType "journal-article" @default.
- W4254755521 hasAuthorship W4254755521A5002793654 @default.
- W4254755521 hasAuthorship W4254755521A5020047598 @default.
- W4254755521 hasConcept C10515644 @default.
- W4254755521 hasConcept C105795698 @default.
- W4254755521 hasConcept C119043178 @default.
- W4254755521 hasConcept C124101348 @default.
- W4254755521 hasConcept C126322002 @default.
- W4254755521 hasConcept C149782125 @default.
- W4254755521 hasConcept C154945302 @default.
- W4254755521 hasConcept C27158222 @default.
- W4254755521 hasConcept C2776214188 @default.
- W4254755521 hasConcept C2908647359 @default.
- W4254755521 hasConcept C33923547 @default.
- W4254755521 hasConcept C41008148 @default.
- W4254755521 hasConcept C50382708 @default.
- W4254755521 hasConcept C71924100 @default.
- W4254755521 hasConcept C99454951 @default.
- W4254755521 hasConceptScore W4254755521C10515644 @default.
- W4254755521 hasConceptScore W4254755521C105795698 @default.
- W4254755521 hasConceptScore W4254755521C119043178 @default.
- W4254755521 hasConceptScore W4254755521C124101348 @default.
- W4254755521 hasConceptScore W4254755521C126322002 @default.
- W4254755521 hasConceptScore W4254755521C149782125 @default.
- W4254755521 hasConceptScore W4254755521C154945302 @default.
- W4254755521 hasConceptScore W4254755521C27158222 @default.
- W4254755521 hasConceptScore W4254755521C2776214188 @default.
- W4254755521 hasConceptScore W4254755521C2908647359 @default.
- W4254755521 hasConceptScore W4254755521C33923547 @default.
- W4254755521 hasConceptScore W4254755521C41008148 @default.
- W4254755521 hasConceptScore W4254755521C50382708 @default.
- W4254755521 hasConceptScore W4254755521C71924100 @default.
- W4254755521 hasConceptScore W4254755521C99454951 @default.
- W4254755521 hasIssue "30" @default.
- W4254755521 hasLocation W42547555211 @default.
- W4254755521 hasOpenAccess W4254755521 @default.
- W4254755521 hasPrimaryLocation W42547555211 @default.
- W4254755521 hasRelatedWork W1975185235 @default.
- W4254755521 hasRelatedWork W1982447720 @default.
- W4254755521 hasRelatedWork W2005600210 @default.
- W4254755521 hasRelatedWork W2013044859 @default.