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- W4254774865 abstract "Ein neues Untersuchungsprinzip für die Wasseranalytik besteht aus einer engen Verknüpfung aus chemischer Analytik und biologischem Wirktest. Biomolekulare Erkennungselemente wie Proteine oder Nukleinsäuren, die in bestimmte Wirkketten eingebunden sind, dienen zur Bindung und selektiven Anreicherung (unbekannter) biowirksamer Substanzen aus einer Wasserprobe. Nach Extraktion bzw. Elution der gesuchten Liganden vom Erkennungsmolekül oder als gesamter Ligand-Zielmolekül-Komplex werden die Liganden nachfolgend mit hochauflösenden, spurenanalytischen Verfahren wie Massenspektrometrie identifiziert. Diese wirkungsbezogene Analytik vereint den Nachweis eines biologischen Wirkpotentials mit der exakten Identifikation der verursachenden Wirkstoffe und wird in Zukunft die Wasseranalytik hinsichtlich Aussage und Kosten optimieren. A new concept is introduced for water analysis, based on a tight hyphenation of chemical analysis and biotests. Biomolecular recognition elements such as proteins and nucleic acids integrated in specific reaction chains are used for binding and selective enrichment of (unknown) bio-effective substances in water samples. After extraction or elution of the ligands or as an entire ligand-target molecule-complex the ligands were subsequently identified by high-resolution, trace analysis instruments such as mass spectrometry. The so-called bioresponse-linked instrumental analysis combines the detection of potential biological effects with the exact identification of the causing agents. This methodolical strategy will help to optimize interpretations and to minimize costs in water analysis." @default.
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- W4254774865 date "2002-06-01" @default.
- W4254774865 modified "2023-10-18" @default.
- W4254774865 title "Wirkungsbezogene Analytik: Zielgerichteter Stoffnachweis im Wasser" @default.
- W4254774865 doi "https://doi.org/10.1002/1521-3781(200206)36:3%3c156::aid-ciuz156%3e3.0.co;2-f" @default.
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