Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254787907> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4254787907 endingPage "3427" @default.
- W4254787907 startingPage "3422" @default.
- W4254787907 abstract "We report a detailed longitudinal study of the first patient to be treated (in 1973) for paroxysmal nocturnal hemoglobinuria (PNH) with syngeneic bone marrow transplantation (BMT). The patient subsequently relapsed with PNH in 1983, and still has PNH to date. Analysis of thePIG-A gene in a recent blood sample showed in exon 6 an insertion-duplication causing a frameshift. Polymerase chain reaction (PCR) amplification of the PIG-A exon 6 from bone marrow (BM) slides obtained before BMT showed that the duplication was not present; instead, we found several single base pair substitutions in exons 2 and 6. Thus, relapse of PNH in this patient was not due to persistence of the original clones; rather, it was associated with the emergence of a new clone. These findings support the notion that the BM environment may create selective conditions favoring the expansion of PNH clones. © 1998 by The American Society of Hematology." @default.
- W4254787907 created "2022-05-12" @default.
- W4254787907 creator A5004217093 @default.
- W4254787907 creator A5035795621 @default.
- W4254787907 creator A5035828284 @default.
- W4254787907 creator A5051266970 @default.
- W4254787907 date "1998-11-01" @default.
- W4254787907 modified "2023-10-17" @default.
- W4254787907 title "New Somatic Mutation in the PIG-A Gene Emerges at Relapse of Paroxysmal Nocturnal Hemoglobinuria" @default.
- W4254787907 cites W123419685 @default.
- W4254787907 cites W127266173 @default.
- W4254787907 cites W1595465814 @default.
- W4254787907 cites W164597523 @default.
- W4254787907 cites W1717575538 @default.
- W4254787907 cites W1760369460 @default.
- W4254787907 cites W1982381511 @default.
- W4254787907 cites W1991319226 @default.
- W4254787907 cites W2002927121 @default.
- W4254787907 cites W2026123252 @default.
- W4254787907 cites W2028396801 @default.
- W4254787907 cites W2032660123 @default.
- W4254787907 cites W2077885787 @default.
- W4254787907 cites W2084185345 @default.
- W4254787907 cites W2097770735 @default.
- W4254787907 cites W2161867618 @default.
- W4254787907 cites W2298830292 @default.
- W4254787907 cites W2424060980 @default.
- W4254787907 cites W64431407 @default.
- W4254787907 doi "https://doi.org/10.1182/blood.v92.9.3422.421k26_3422_3427" @default.
- W4254787907 hasPublicationYear "1998" @default.
- W4254787907 type Work @default.
- W4254787907 citedByCount "5" @default.
- W4254787907 crossrefType "journal-article" @default.
- W4254787907 hasAuthorship W4254787907A5004217093 @default.
- W4254787907 hasAuthorship W4254787907A5035795621 @default.
- W4254787907 hasAuthorship W4254787907A5035828284 @default.
- W4254787907 hasAuthorship W4254787907A5051266970 @default.
- W4254787907 hasConcept C104317684 @default.
- W4254787907 hasConcept C109159458 @default.
- W4254787907 hasConcept C126322002 @default.
- W4254787907 hasConcept C194409129 @default.
- W4254787907 hasConcept C203014093 @default.
- W4254787907 hasConcept C2777346216 @default.
- W4254787907 hasConcept C2778248108 @default.
- W4254787907 hasConcept C2778639011 @default.
- W4254787907 hasConcept C2780007613 @default.
- W4254787907 hasConcept C2780525284 @default.
- W4254787907 hasConcept C28328180 @default.
- W4254787907 hasConcept C29906990 @default.
- W4254787907 hasConcept C36823959 @default.
- W4254787907 hasConcept C54355233 @default.
- W4254787907 hasConcept C71924100 @default.
- W4254787907 hasConcept C7602840 @default.
- W4254787907 hasConcept C81089528 @default.
- W4254787907 hasConcept C86803240 @default.
- W4254787907 hasConceptScore W4254787907C104317684 @default.
- W4254787907 hasConceptScore W4254787907C109159458 @default.
- W4254787907 hasConceptScore W4254787907C126322002 @default.
- W4254787907 hasConceptScore W4254787907C194409129 @default.
- W4254787907 hasConceptScore W4254787907C203014093 @default.
- W4254787907 hasConceptScore W4254787907C2777346216 @default.
- W4254787907 hasConceptScore W4254787907C2778248108 @default.
- W4254787907 hasConceptScore W4254787907C2778639011 @default.
- W4254787907 hasConceptScore W4254787907C2780007613 @default.
- W4254787907 hasConceptScore W4254787907C2780525284 @default.
- W4254787907 hasConceptScore W4254787907C28328180 @default.
- W4254787907 hasConceptScore W4254787907C29906990 @default.
- W4254787907 hasConceptScore W4254787907C36823959 @default.
- W4254787907 hasConceptScore W4254787907C54355233 @default.
- W4254787907 hasConceptScore W4254787907C71924100 @default.
- W4254787907 hasConceptScore W4254787907C7602840 @default.
- W4254787907 hasConceptScore W4254787907C81089528 @default.
- W4254787907 hasConceptScore W4254787907C86803240 @default.
- W4254787907 hasIssue "9" @default.
- W4254787907 hasLocation W42547879071 @default.
- W4254787907 hasOpenAccess W4254787907 @default.
- W4254787907 hasPrimaryLocation W42547879071 @default.
- W4254787907 hasRelatedWork W142766978 @default.
- W4254787907 hasRelatedWork W1569661065 @default.
- W4254787907 hasRelatedWork W1958056281 @default.
- W4254787907 hasRelatedWork W2008673097 @default.
- W4254787907 hasRelatedWork W2093098007 @default.
- W4254787907 hasRelatedWork W2126951952 @default.
- W4254787907 hasRelatedWork W2340473219 @default.
- W4254787907 hasRelatedWork W2980212795 @default.
- W4254787907 hasRelatedWork W4235681974 @default.
- W4254787907 hasRelatedWork W779733153 @default.
- W4254787907 hasVolume "92" @default.
- W4254787907 isParatext "false" @default.
- W4254787907 isRetracted "false" @default.
- W4254787907 workType "article" @default.