Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254789629> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4254789629 abstract "Abstract Background: Several studies have investigated the value of alpha-synuclein assay in the cerebrospinal fluid (CSF) of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) patients in the differential diagnosis of these two pathologies. However, very few studies have focused on this assay in AD and DLB patients at the MCI stage. Methods: All patients were enrolled under a hospital clinical research protocol from the tertiary Memory Clinic (CM2R) of Alsace, France, by an experienced team of clinicians. A total of 166 patients were included in this study: 21 control subjects (CS), 51 patients with DLB at the prodromal stage (pro-DLB), 16 patients with DLB at the demented stage (DLB-d), 33 AD patients at the prodromal stage (pro-AD), 32 AD patients at the demented stage (AD-d) and 13 patients with mixed pathology (AD+DLB). CSF levels of total alpha-synuclein were assessed using a commercial enzyme-linked immunosorbent assay (ELISA) for alpha-synuclein (AJ Roboscreen). Alzheimer’s biomarkers (t-Tau, P-Tau, Aβ42 and Aβ40) were also measured. Results: The alpha-synuclein assays showed a significant difference between the AD and DLB groups. Total alpha-synuclein levels were significantly higher in AD patients than in DLB patients. However, the ROC curves show a moderate discriminating power between AD and DLB (AUC = 0.78) which does not improve the discriminating power of the combination of Alzheimer biomarkers (AUC = 0.95 with or without alpha-synuclein). Interestingly, the levels appeared to be altered from the prodromal stage in both AD and DLB. Conclusions: The modification of total alpha-synuclein levels in the CSF of patients occurs early, from the prodromal stage. The adding of alpha-synuclein total to the combination of Alzheimer’s biomarker does not improve the differential diagnosis between AD and DLB. Trial registration : ClinicalTrials.gov, (AlphaLewyMa, Identifier: NCT01876459)" @default.
- W4254789629 created "2022-05-12" @default.
- W4254789629 creator A5000926397 @default.
- W4254789629 creator A5001079402 @default.
- W4254789629 creator A5002992369 @default.
- W4254789629 creator A5007707721 @default.
- W4254789629 creator A5029284890 @default.
- W4254789629 creator A5031903426 @default.
- W4254789629 creator A5032163696 @default.
- W4254789629 creator A5035037646 @default.
- W4254789629 creator A5040128077 @default.
- W4254789629 creator A5056462223 @default.
- W4254789629 creator A5061085632 @default.
- W4254789629 creator A5072010668 @default.
- W4254789629 creator A5082040573 @default.
- W4254789629 creator A5089934869 @default.
- W4254789629 creator A5091274060 @default.
- W4254789629 date "2020-09-11" @default.
- W4254789629 modified "2023-09-27" @default.
- W4254789629 title "Differential diagnostic value of total alpha-synuclein assay in the cerebrospinal fluid between Alzheimer's disease and dementia with Lewy bodies from the prodromal stage" @default.
- W4254789629 doi "https://doi.org/10.21203/rs.3.rs-18905/v5" @default.
- W4254789629 hasPublicationYear "2020" @default.
- W4254789629 type Work @default.
- W4254789629 citedByCount "0" @default.
- W4254789629 crossrefType "posted-content" @default.
- W4254789629 hasAuthorship W4254789629A5000926397 @default.
- W4254789629 hasAuthorship W4254789629A5001079402 @default.
- W4254789629 hasAuthorship W4254789629A5002992369 @default.
- W4254789629 hasAuthorship W4254789629A5007707721 @default.
- W4254789629 hasAuthorship W4254789629A5029284890 @default.
- W4254789629 hasAuthorship W4254789629A5031903426 @default.
- W4254789629 hasAuthorship W4254789629A5032163696 @default.
- W4254789629 hasAuthorship W4254789629A5035037646 @default.
- W4254789629 hasAuthorship W4254789629A5040128077 @default.
- W4254789629 hasAuthorship W4254789629A5056462223 @default.
- W4254789629 hasAuthorship W4254789629A5061085632 @default.
- W4254789629 hasAuthorship W4254789629A5072010668 @default.
- W4254789629 hasAuthorship W4254789629A5082040573 @default.
- W4254789629 hasAuthorship W4254789629A5089934869 @default.
- W4254789629 hasAuthorship W4254789629A5091274060 @default.
- W4254789629 hasBestOaLocation W42547896291 @default.
- W4254789629 hasConcept C126322002 @default.
- W4254789629 hasConcept C142724271 @default.
- W4254789629 hasConcept C146357865 @default.
- W4254789629 hasConcept C151730666 @default.
- W4254789629 hasConcept C2778548049 @default.
- W4254789629 hasConcept C2779134260 @default.
- W4254789629 hasConcept C2779483572 @default.
- W4254789629 hasConcept C2779651940 @default.
- W4254789629 hasConcept C2779734285 @default.
- W4254789629 hasConcept C2780801072 @default.
- W4254789629 hasConcept C2781449126 @default.
- W4254789629 hasConcept C2910528735 @default.
- W4254789629 hasConcept C502032728 @default.
- W4254789629 hasConcept C71924100 @default.
- W4254789629 hasConcept C86803240 @default.
- W4254789629 hasConcept C90924648 @default.
- W4254789629 hasConceptScore W4254789629C126322002 @default.
- W4254789629 hasConceptScore W4254789629C142724271 @default.
- W4254789629 hasConceptScore W4254789629C146357865 @default.
- W4254789629 hasConceptScore W4254789629C151730666 @default.
- W4254789629 hasConceptScore W4254789629C2778548049 @default.
- W4254789629 hasConceptScore W4254789629C2779134260 @default.
- W4254789629 hasConceptScore W4254789629C2779483572 @default.
- W4254789629 hasConceptScore W4254789629C2779651940 @default.
- W4254789629 hasConceptScore W4254789629C2779734285 @default.
- W4254789629 hasConceptScore W4254789629C2780801072 @default.
- W4254789629 hasConceptScore W4254789629C2781449126 @default.
- W4254789629 hasConceptScore W4254789629C2910528735 @default.
- W4254789629 hasConceptScore W4254789629C502032728 @default.
- W4254789629 hasConceptScore W4254789629C71924100 @default.
- W4254789629 hasConceptScore W4254789629C86803240 @default.
- W4254789629 hasConceptScore W4254789629C90924648 @default.
- W4254789629 hasLocation W42547896291 @default.
- W4254789629 hasLocation W42547896292 @default.
- W4254789629 hasLocation W42547896293 @default.
- W4254789629 hasLocation W42547896294 @default.
- W4254789629 hasLocation W42547896295 @default.
- W4254789629 hasLocation W42547896296 @default.
- W4254789629 hasLocation W42547896297 @default.
- W4254789629 hasLocation W42547896298 @default.
- W4254789629 hasOpenAccess W4254789629 @default.
- W4254789629 hasPrimaryLocation W42547896291 @default.
- W4254789629 hasRelatedWork W10370648 @default.
- W4254789629 hasRelatedWork W12347255 @default.
- W4254789629 hasRelatedWork W17613042 @default.
- W4254789629 hasRelatedWork W17785474 @default.
- W4254789629 hasRelatedWork W19615207 @default.
- W4254789629 hasRelatedWork W20177886 @default.
- W4254789629 hasRelatedWork W2213363 @default.
- W4254789629 hasRelatedWork W5285369 @default.
- W4254789629 hasRelatedWork W16667794 @default.
- W4254789629 hasRelatedWork W20877732 @default.
- W4254789629 isParatext "false" @default.
- W4254789629 isRetracted "false" @default.
- W4254789629 workType "article" @default.