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- W4254792007 abstract "Abstract Background: The global prevalent ptxP3 strains varies from about 10% to about 50% of circulating B. pertussis population in different areas of China. Methods To investigate the difference of vaccination status between different genotypes in the circulating B. pertussis after 10 years of acellular pertussis vaccine (aPV) used in China. The nasopharyngeal swabs and isolates of B. pertussis from these patients were used to perform genotyping of antigen genes. We use antibiotic susceptibility test against erythromycin and sequencing methods for site 2047 of 23S rRNA to determine the resistance status. Results The ptxP1 allele with erythromycin resistant strains infection (total of 449 samples) consisted of 84.70% to 96.70% from 2012 to 2016. Only 2 of the 21 ptxP3 strains infected in children vaccinated with co-purified aPV, that showed a significant difference between the ptxP1 strains does (χ 2 =6.87, P=0.032). Conclusions The ptxP1 allele with erythromycin resistant B. pertussis was steadily increased in Xi’an, China from 2012 to 2016, where co-purified aPV was prevalence used . We assumed that the co-purified aPV might protect against ptxP3 strains more efficient, which generated a rare chance for ptxP3 strains to be under the antibiotic pressure and further developed to be erythromycin resistance. A further cohort study and the mechanisms of the additional antigen proteins of co-purified aPV protected against B. pertussis should be consideration." @default.
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- W4254792007 date "2020-02-19" @default.
- W4254792007 modified "2023-09-27" @default.
- W4254792007 title "The global prevalence ptxP3 lineage of Bordetella pertussis was rare in young Children with the Co-purified aPV vaccination: a 5 years retrospective study" @default.
- W4254792007 doi "https://doi.org/10.21203/rs.2.23947/v1" @default.
- W4254792007 hasPublicationYear "2020" @default.
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