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- W4254829508 abstract "Presenter: Asama Khan MD | SUNY Upstate Medical University Background: Data on morbidity and mortality following liver resection after radioembolization (Y90) are limited and controversial. Some studies report a high mortality rate, whereas others note the resection to be safe. Therefore, we aimed to perform a systematic review and meta-analysis of perioperative morbidity and mortality after liver resection in the setting of previous Y90 treatment. Methods: We conducted a PubMed search to identify studies of liver resection after previous Y90 treatment. A backward search through references of the selected studies was also performed to ensure a thorough selection of studies. The 2009 PRISMA guidelines were followed and STATA 16.1 software was used for statistical analysis. Results: A total of 14 studies reporting on 260 patients who underwent liver resection after Y90 met the inclusion criteria, and were included in the meta-analysis. Meta-analysis of 30-day mortality rates yielded pooled mortality of 0.8% [95% confidence interval (CI) 0.0 – 4.3%]. Four studies (139 patients) reported a pooled 90-day mortality of 3.6% (95% CI 0.6 – 8.2%). Median time to resection after Y90 ranged from 2.0 – 12.5 months in various studies. In all studies where the median resection was undertaken eight or more months after Y90, zero 30-day mortality was reported. Meta-analysis of overall grade 3 or higher morbidity noted a rate of 27% (95% CI 16 – 38%). Conclusion: Liver resection after Y90 is safe. Delaying resection for a period of time after Y90 may further decrease mortality and improve surgical outcomes." @default.
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- W4254829508 date "2021-01-01" @default.
- W4254829508 modified "2023-10-16" @default.
- W4254829508 title "Liver resection after Y-90 radioembolization: a systematic review and meta-analysis of perioperative morbidity and mortality" @default.
- W4254829508 doi "https://doi.org/10.1016/j.hpb.2021.06.289" @default.
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