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- W4254846074 abstract "Selecting embryos with the highest implantation potential is the most important challenges in the field of Assisted Reproduction. Previously, morphologic criteria were the most commonly used standards for embryo selection. The introduction of preimplantation genetic screen (PGS-24) provides a novel method to determinate embryo competence. Our goal was to evaluate the clinical outcomes in patients with and without PGS-24 testing. Retrospective study. 532 patients who underwent FET using vitrified-thawed blastocysts at our fertility center from Jan 2013 to Dec 2013 were included. 253 received PGS-24 testing and 279 patient did not. Patients were divided into 5 age groups (<35, 35-37, 38-40, >40 and donor). Clinical pregnancy rate and implantation rate were compared. Clinical pregnancy rate and implantation rate for each age group were generally higher in the PGS compared to the non-PGS group (Table 1). The mean number of embryos transferred was significantly lower in PGS group vs non-PGS. These data demonstrate significant improvements in clinical outcomes in patients with PGS-24 testing, suggesting that PGS-24 is an effective method to determine blastocyst competence. Furthermore, PGS-24 screening facilitates elective single embryo transfer while reducing the probability of ovarian hyperstimulation syndrome and avoiding multiple gestation.Tabled 1COMPARISONS OF CLINICAL OUTCOMES BETWEEN PATIENTS WITH AND WITHOUT PGS-24 SCREENINGTable 1 (A) Sample SizeAge GroupsSample SizePGS-24NO PGS-24DONORN=82N=103<35N=67N=8835-37N=42N=4238-40N=39N=25>40N=23N=21Table 1 (B) Comparisons of Clinical Pregnancy Rate and On Going Clinical Pregnancy RateAge GroupClinical Pregnancy Rate (%)On Going Pregnancy Rate (%)PGS-24NO PGS-24p valuePGS-24No PGS-24p valuedonor66440.00*54380.04*<3569630.4260510.2935-3771520.0767450.04*38-4067600.5956480.51>4052190.04*43100.02*Table 1 (C) Comparisons of Implantation Rate and Implantation Leading to Ongoing PregnancyAge GroupsImplantation Rate (%)Implantation Leading to Ongoing PregnancyPGS-24No PGS-24P valuePGS-24No PGS-24p valuedonor55280.00*47230.00*<3558460.1150380.1135-3761270.00*58210.00*38-4052380.2046350.29>405340.00*4440.00*Table 1 D. Number of Transferred EmbryosAge GroupsNumber of Transferred EmbryosPGS-24No PGS-24p valuedonor1.7±0.542.1±0.900.00*<351.4±0.521.8±0.530.00*35-371.4±0.671.9±0.660.00*38-401.5±0.552.0±1.070.01*>401.5±0.592.0±0.760.02** P<0.05 Significant difference Open table in a new tab" @default.
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- W4254846074 date "2014-09-01" @default.
- W4254846074 modified "2023-10-16" @default.
- W4254846074 title "Microarray preimplantation genetic screen significantly improves clinical outcomes with vitrified-thawed embryo transfer" @default.
- W4254846074 doi "https://doi.org/10.1016/j.fertnstert.2014.07.601" @default.
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