Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254853312> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4254853312 endingPage "2004" @default.
- W4254853312 startingPage "1997" @default.
- W4254853312 abstract "BACKGROUND Neuroblastoma is the most common extracranial solid tumor among pediatric patients, and orbital metastatic disease is not uncommon in these children. Physical signs as a consequence of orbital metastases, such as proptosis and periorbital ecchymosis, frequently are encountered. However, subsequent blindness is rare. METHODS A retrospective study was conducted to determine the incidence, related physical findings, treatment, and outcome of children who developed visual loss during treatment for neuroblastoma. Medical records for a 24-year period (1971-1994) were reviewed to identify these patients. The charts, diagnostic imaging studies, and autopsy material of these patients were reviewed. RESULTS Of the 450 patients treated for neuroblastoma at the study institution during this period, 47 presented with abnormalities in physical examination of the eye. Eight of these 47 patients and 7 others developed visual loss in at least 1 eye during the first week after diagnosis (n = 5), during primary therapy (n = 6), at recurrence (n = 2), or after completion of therapy (n = 2). In ten patients the visual loss was a direct consequence of the primary disease process, whereas a direct relationship between loss of vision and neuroblastoma could not be identified in the remaining five patients. Proptosis and periorbital ecchymosis were the most common associated physical findings. Although ten patients received steroids and eight received radiation, visual loss could not be prevented or reversed in these patients. CONCLUSIONS Early initiation of effective, multiagent chemotherapy remains the primary approach for the treatment of neuroblastoma and its ophthalmologic complications. Radiation therapy and steroids may have benefit but failed to show good effect in this series. The prevention and treatment of blindness is probably most relevant in infants and children age < 2 years because they have the best chance for cure. Cancer 1997; 80:1997-2004. © 1997 American Cancer Society." @default.
- W4254853312 created "2022-05-12" @default.
- W4254853312 creator A5000464642 @default.
- W4254853312 creator A5000723615 @default.
- W4254853312 creator A5009480626 @default.
- W4254853312 creator A5012423746 @default.
- W4254853312 creator A5034374604 @default.
- W4254853312 creator A5066410804 @default.
- W4254853312 creator A5080396108 @default.
- W4254853312 date "1997-11-15" @default.
- W4254853312 modified "2023-09-25" @default.
- W4254853312 title "Blindness in children with neuroblastoma" @default.
- W4254853312 doi "https://doi.org/10.1002/(sici)1097-0142(19971115)80:10<1997::aid-cncr18>3.3.co;2-c" @default.
- W4254853312 hasPublicationYear "1997" @default.
- W4254853312 type Work @default.
- W4254853312 citedByCount "1" @default.
- W4254853312 crossrefType "journal-article" @default.
- W4254853312 hasAuthorship W4254853312A5000464642 @default.
- W4254853312 hasAuthorship W4254853312A5000723615 @default.
- W4254853312 hasAuthorship W4254853312A5009480626 @default.
- W4254853312 hasAuthorship W4254853312A5012423746 @default.
- W4254853312 hasAuthorship W4254853312A5034374604 @default.
- W4254853312 hasAuthorship W4254853312A5066410804 @default.
- W4254853312 hasAuthorship W4254853312A5080396108 @default.
- W4254853312 hasConcept C120665830 @default.
- W4254853312 hasConcept C121332964 @default.
- W4254853312 hasConcept C126322002 @default.
- W4254853312 hasConcept C141071460 @default.
- W4254853312 hasConcept C187212893 @default.
- W4254853312 hasConcept C195910791 @default.
- W4254853312 hasConcept C2776715637 @default.
- W4254853312 hasConcept C2779134260 @default.
- W4254853312 hasConcept C2779663748 @default.
- W4254853312 hasConcept C509974204 @default.
- W4254853312 hasConcept C527108885 @default.
- W4254853312 hasConcept C54355233 @default.
- W4254853312 hasConcept C61511704 @default.
- W4254853312 hasConcept C71924100 @default.
- W4254853312 hasConcept C81885089 @default.
- W4254853312 hasConcept C86803240 @default.
- W4254853312 hasConceptScore W4254853312C120665830 @default.
- W4254853312 hasConceptScore W4254853312C121332964 @default.
- W4254853312 hasConceptScore W4254853312C126322002 @default.
- W4254853312 hasConceptScore W4254853312C141071460 @default.
- W4254853312 hasConceptScore W4254853312C187212893 @default.
- W4254853312 hasConceptScore W4254853312C195910791 @default.
- W4254853312 hasConceptScore W4254853312C2776715637 @default.
- W4254853312 hasConceptScore W4254853312C2779134260 @default.
- W4254853312 hasConceptScore W4254853312C2779663748 @default.
- W4254853312 hasConceptScore W4254853312C509974204 @default.
- W4254853312 hasConceptScore W4254853312C527108885 @default.
- W4254853312 hasConceptScore W4254853312C54355233 @default.
- W4254853312 hasConceptScore W4254853312C61511704 @default.
- W4254853312 hasConceptScore W4254853312C71924100 @default.
- W4254853312 hasConceptScore W4254853312C81885089 @default.
- W4254853312 hasConceptScore W4254853312C86803240 @default.
- W4254853312 hasIssue "10" @default.
- W4254853312 hasLocation W42548533121 @default.
- W4254853312 hasOpenAccess W4254853312 @default.
- W4254853312 hasPrimaryLocation W42548533121 @default.
- W4254853312 hasRelatedWork W1967767793 @default.
- W4254853312 hasRelatedWork W2038215193 @default.
- W4254853312 hasRelatedWork W2099063876 @default.
- W4254853312 hasRelatedWork W2136015758 @default.
- W4254853312 hasRelatedWork W2149347908 @default.
- W4254853312 hasRelatedWork W2167519803 @default.
- W4254853312 hasRelatedWork W2409957712 @default.
- W4254853312 hasRelatedWork W2414366497 @default.
- W4254853312 hasRelatedWork W2466822063 @default.
- W4254853312 hasRelatedWork W2128730845 @default.
- W4254853312 hasVolume "80" @default.
- W4254853312 isParatext "false" @default.
- W4254853312 isRetracted "false" @default.
- W4254853312 workType "article" @default.