Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254853899> ?p ?o ?g. }
- W4254853899 endingPage "180" @default.
- W4254853899 startingPage "173" @default.
- W4254853899 abstract "Contraction of the orbicularis oculi muscle in response to a sudden loud sound (acoustic startle response) and the N1/P2 component of the auditory evoked potential are both attenuated when a brief low-intensity stimulus is presented 30-500 ms before the ‘startle-eliciting’ stimulus (PPI). Here, we report the effects of the ‘atypical’ antipsychotic drug quetiapine and the ‘conventional’ antipsychotic haloperidol on these responses. Sixteen males (aged 19-38 years) participated in four sessions at 7-day intervals, in which they received quetiapine 12.5 mg, quetiapine 25 mg, haloperidol 3 mg and placebo, according to a balanced double-blind design. Electromyographic (EMG) responses of the orbicularis oculi muscle and N1/P2 auditory evoked potentials were recorded in a 20-min session, 2 h after treatment. Subjects received 40 trials in which 1-kHz sounds were presented: (i) 40 ms, 115 dB (‘pulse alone’ trials) and (ii) 40 ms, 85 dB, followed after 120 ms by 40 ms, 115 dB (‘prepulse/pulse’ trials). Mean amplitudes of the EMG response and the N1/P2 potential were derived from the pulse-alone trials and, in each case, percentage PPI was calculated. Serum prolactin was measured after each treatment, and autonomic (heart rate, blood pressure, salivation) and psychological (visual analogue self-ratings of mood and alertness, critical flicker fusion frequency) measures were taken before and after each treatment. Quetiapine 12.5 mg and 25 mg significantly reduced the amplitude of the EMG response without altering its inhibition by prepulses; haloperidol had no effect on EMG response amplitude or PPI. Neither drug affected N1/P2 amplitude or PPI of this response. Quetiapine, but not haloperidol, reduced subjective alertness and critical flicker fusion frequency. Haloperidol, but not quetiapine, elevated serum prolactin level. The ability of quetiapine to attenuate the startle response may reflect its sedative action." @default.
- W4254853899 created "2022-05-12" @default.
- W4254853899 creator A5032542523 @default.
- W4254853899 creator A5035477027 @default.
- W4254853899 creator A5041044070 @default.
- W4254853899 creator A5079250076 @default.
- W4254853899 creator A5087372773 @default.
- W4254853899 creator A5090545470 @default.
- W4254853899 date "2004-06-01" @default.
- W4254853899 modified "2023-10-17" @default.
- W4254853899 title "Effects of Quetiapine and Haloperidol on Prepulse Inhibition of the Acoustic Startle (Eyeblink) Response and the N1/P2 Auditory Evoked Response in Man" @default.
- W4254853899 cites W1545972494 @default.
- W4254853899 cites W1550888725 @default.
- W4254853899 cites W1969846620 @default.
- W4254853899 cites W1971880926 @default.
- W4254853899 cites W1974389014 @default.
- W4254853899 cites W1976699309 @default.
- W4254853899 cites W1980967004 @default.
- W4254853899 cites W1986859027 @default.
- W4254853899 cites W1990414759 @default.
- W4254853899 cites W1990555605 @default.
- W4254853899 cites W1993482722 @default.
- W4254853899 cites W2006740644 @default.
- W4254853899 cites W2012786085 @default.
- W4254853899 cites W2014036031 @default.
- W4254853899 cites W2016913181 @default.
- W4254853899 cites W2021454992 @default.
- W4254853899 cites W2028428443 @default.
- W4254853899 cites W2030247720 @default.
- W4254853899 cites W2035170991 @default.
- W4254853899 cites W2036833511 @default.
- W4254853899 cites W2041365278 @default.
- W4254853899 cites W2055837527 @default.
- W4254853899 cites W2060441063 @default.
- W4254853899 cites W2060802427 @default.
- W4254853899 cites W2060884332 @default.
- W4254853899 cites W2061452688 @default.
- W4254853899 cites W2070605348 @default.
- W4254853899 cites W2073113115 @default.
- W4254853899 cites W2073429353 @default.
- W4254853899 cites W2074319107 @default.
- W4254853899 cites W2079902803 @default.
- W4254853899 cites W2079984624 @default.
- W4254853899 cites W2080825784 @default.
- W4254853899 cites W2096266931 @default.
- W4254853899 cites W2097759310 @default.
- W4254853899 cites W2107876659 @default.
- W4254853899 cites W2110183017 @default.
- W4254853899 cites W2120466621 @default.
- W4254853899 cites W2124389210 @default.
- W4254853899 cites W2157088459 @default.
- W4254853899 cites W2159648246 @default.
- W4254853899 cites W2161020548 @default.
- W4254853899 cites W2164699154 @default.
- W4254853899 cites W2238215940 @default.
- W4254853899 cites W2329891286 @default.
- W4254853899 cites W3021847224 @default.
- W4254853899 doi "https://doi.org/10.1177/0269881104042615" @default.
- W4254853899 hasPublicationYear "2004" @default.
- W4254853899 type Work @default.
- W4254853899 citedByCount "28" @default.
- W4254853899 countsByYear W42548538992012 @default.
- W4254853899 countsByYear W42548538992014 @default.
- W4254853899 countsByYear W42548538992015 @default.
- W4254853899 countsByYear W42548538992016 @default.
- W4254853899 countsByYear W42548538992017 @default.
- W4254853899 countsByYear W42548538992019 @default.
- W4254853899 countsByYear W42548538992020 @default.
- W4254853899 countsByYear W42548538992022 @default.
- W4254853899 crossrefType "journal-article" @default.
- W4254853899 hasAuthorship W4254853899A5032542523 @default.
- W4254853899 hasAuthorship W4254853899A5035477027 @default.
- W4254853899 hasAuthorship W4254853899A5041044070 @default.
- W4254853899 hasAuthorship W4254853899A5079250076 @default.
- W4254853899 hasAuthorship W4254853899A5087372773 @default.
- W4254853899 hasAuthorship W4254853899A5090545470 @default.
- W4254853899 hasConcept C118552586 @default.
- W4254853899 hasConcept C137431309 @default.
- W4254853899 hasConcept C141071460 @default.
- W4254853899 hasConcept C141421786 @default.
- W4254853899 hasConcept C15744967 @default.
- W4254853899 hasConcept C169760540 @default.
- W4254853899 hasConcept C2776082946 @default.
- W4254853899 hasConcept C2776412080 @default.
- W4254853899 hasConcept C2777845764 @default.
- W4254853899 hasConcept C2780634440 @default.
- W4254853899 hasConcept C2780948584 @default.
- W4254853899 hasConcept C2781302119 @default.
- W4254853899 hasConcept C2909172351 @default.
- W4254853899 hasConcept C42219234 @default.
- W4254853899 hasConcept C513476851 @default.
- W4254853899 hasConcept C548259974 @default.
- W4254853899 hasConcept C71924100 @default.
- W4254853899 hasConcept C83974742 @default.
- W4254853899 hasConceptScore W4254853899C118552586 @default.
- W4254853899 hasConceptScore W4254853899C137431309 @default.
- W4254853899 hasConceptScore W4254853899C141071460 @default.
- W4254853899 hasConceptScore W4254853899C141421786 @default.