FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254883446> ?p ?o ?g. }

• W4254883446 endingPage "715" @default.
• W4254883446 startingPage "708" @default.
• W4254883446 abstract "Plasmodium falciparum causes the most severe malaria pathogen and has developed resistance to existing drugs making it indispensable to discover new drugs. In order to predict drug targets in silico, a useful model for the metabolism is needed. However, automatically reconstructed network models typically cover more non-confirmed enzymes than confirmed enzymes of known gene products. Furthermore, it needs to be considered that the parasite takes advantage of the metabolism of the host. We compared several reconstructed network models and aimed to find the best suitable reconstruction for detecting drug targets in silico. We computationally reconstructed the metabolism based on automatically inferred enzymes and compared this with a reconstructed model that was based only on enzymes whose coding genes are known. Additionally, we tested if integrating enzymes of the host cell is beneficial for such an analysis. We employed several well established criteria for defining essential enzymes including chokepoints, betweenness centrality (or load-points), connectivity and the diameter of the networks. Comparing the modeling results with a comprehensive list of known drug targets for P. falciparum, showed that we had the best discovery success with a network model consisting only of enzymes from the parasite alone which coding genes were known." @default.
• W4254883446 created "2022-05-12" @default.
• W4254883446 creator A5077171389 @default.
• W4254883446 creator A5077200146 @default.
• W4254883446 creator A5079939031 @default.
• W4254883446 creator A5087589926 @default.
• W4254883446 date "2011-06-01" @default.
• W4254883446 modified "2023-09-27" @default.
• W4254883446 title "Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico" @default.
• W4254883446 cites W1976242931 @default.
• W4254883446 cites W1983202741 @default.
• W4254883446 cites W1991905887 @default.
• W4254883446 cites W2005740247 @default.
• W4254883446 cites W2011584557 @default.
• W4254883446 cites W2041654139 @default.
• W4254883446 cites W2044531373 @default.
• W4254883446 cites W2047232558 @default.
• W4254883446 cites W2074443723 @default.
• W4254883446 cites W2076247413 @default.
• W4254883446 cites W2094491295 @default.
• W4254883446 cites W2111421616 @default.
• W4254883446 cites W2111825982 @default.
• W4254883446 cites W2118446779 @default.
• W4254883446 cites W2124540200 @default.
• W4254883446 cites W2132285289 @default.
• W4254883446 cites W2134394193 @default.
• W4254883446 cites W2136623181 @default.
• W4254883446 cites W2155331065 @default.
• W4254883446 cites W2162215524 @default.
• W4254883446 cites W2163480486 @default.
• W4254883446 cites W2167867998 @default.
• W4254883446 cites W2170427655 @default.
• W4254883446 cites W3103071483 @default.
• W4254883446 cites W3148508445 @default.
• W4254883446 cites W4294216483 @default.
• W4254883446 doi "https://doi.org/10.1016/j.meegid.2011.04.013" @default.
• W4254883446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21515412" @default.
• W4254883446 hasPublicationYear "2011" @default.
• W4254883446 type Work @default.
• W4254883446 citedByCount "11" @default.
• W4254883446 countsByYear W42548834462012 @default.
• W4254883446 countsByYear W42548834462013 @default.
• W4254883446 countsByYear W42548834462015 @default.
• W4254883446 countsByYear W42548834462017 @default.
• W4254883446 countsByYear W42548834462020 @default.
• W4254883446 countsByYear W42548834462021 @default.
• W4254883446 countsByYear W42548834462022 @default.
• W4254883446 crossrefType "journal-article" @default.
• W4254883446 hasAuthorship W4254883446A5077171389 @default.
• W4254883446 hasAuthorship W4254883446A5077200146 @default.
• W4254883446 hasAuthorship W4254883446A5079939031 @default.
• W4254883446 hasAuthorship W4254883446A5087589926 @default.
• W4254883446 hasConcept C101810790 @default.
• W4254883446 hasConcept C104317684 @default.
• W4254883446 hasConcept C114614502 @default.
• W4254883446 hasConcept C117045392 @default.
• W4254883446 hasConcept C203014093 @default.
• W4254883446 hasConcept C2775905019 @default.
• W4254883446 hasConcept C2778048844 @default.
• W4254883446 hasConcept C2778371730 @default.
• W4254883446 hasConcept C33923547 @default.
• W4254883446 hasConcept C41008148 @default.
• W4254883446 hasConcept C53811970 @default.
• W4254883446 hasConcept C54355233 @default.
• W4254883446 hasConcept C60644358 @default.
• W4254883446 hasConcept C70721500 @default.
• W4254883446 hasConcept C74187038 @default.
• W4254883446 hasConcept C86803240 @default.
• W4254883446 hasConceptScore W4254883446C101810790 @default.
• W4254883446 hasConceptScore W4254883446C104317684 @default.
• W4254883446 hasConceptScore W4254883446C114614502 @default.
• W4254883446 hasConceptScore W4254883446C117045392 @default.
• W4254883446 hasConceptScore W4254883446C203014093 @default.
• W4254883446 hasConceptScore W4254883446C2775905019 @default.
• W4254883446 hasConceptScore W4254883446C2778048844 @default.
• W4254883446 hasConceptScore W4254883446C2778371730 @default.
• W4254883446 hasConceptScore W4254883446C33923547 @default.
• W4254883446 hasConceptScore W4254883446C41008148 @default.
• W4254883446 hasConceptScore W4254883446C53811970 @default.
• W4254883446 hasConceptScore W4254883446C54355233 @default.
• W4254883446 hasConceptScore W4254883446C60644358 @default.
• W4254883446 hasConceptScore W4254883446C70721500 @default.
• W4254883446 hasConceptScore W4254883446C74187038 @default.
• W4254883446 hasConceptScore W4254883446C86803240 @default.
• W4254883446 hasIssue "4" @default.
• W4254883446 hasLocation W42548834461 @default.
• W4254883446 hasLocation W42548834462 @default.
• W4254883446 hasOpenAccess W4254883446 @default.
• W4254883446 hasPrimaryLocation W42548834461 @default.
• W4254883446 hasRelatedWork W2006763720 @default.
• W4254883446 hasRelatedWork W2072067873 @default.
• W4254883446 hasRelatedWork W2083947856 @default.
• W4254883446 hasRelatedWork W2126314095 @default.
• W4254883446 hasRelatedWork W2136623181 @default.
• W4254883446 hasRelatedWork W2472804037 @default.
• W4254883446 hasRelatedWork W2740308114 @default.
• W4254883446 hasRelatedWork W311212352 @default.
• W4254883446 hasRelatedWork W4225892111 @default.

• next