FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254925344> ?p ?o ?g. }

• W4254925344 abstract "Information is coded in the brain as patterns of electrical impulses that are transmitted along nerve processes. These impulses are passed from one neuron to the next primarily at chemical synapses where the electrical event is converted to the release of a neurotransmitter substance that activates the next neuron in the pathway. Neurotransmitter release is triggered by the opening of ‘voltage-sensitive’ calcium channels, the admission of a small pulse of Ca2+ ions and the binding of these ions to the neurotransmitter secretion apparatus culminating in the fusion and discharge of a transmitter-filled secretory vesicle. Increasing evidence suggests that most synapses an individual release site is gated by ion influx through one or more nearby calcium channels. In this section, we explore the physiology of this impulse-to-secretion gating mechanism. Key Concepts Information is transmitted between one neuron and the next at synapses where the nerve fibre terminal of the upstream (presynaptic) neuron contacts the surface membrane of the downstream (postsynaptic) one. Most synapses transmit by secreting a chemical neurotransmitter across the narrow space between pre- and postsynaptic surface membranes. Transmitter secretion is triggered by an electrical impulse that travels down the presynaptic nerve fibre to the terminal. Neurotransmitter is stored in tiny membrane ‘packets’ called synaptic vesicles which can be triggered to secrete by fusing with the presynaptic membrane at the ‘transmitter release site’. The synaptic vesicles are ‘docked’ at the release site ready for secretion. Influx of calcium ions through selective voltage-sensitive ion channels (calcium channels) plays a key role to link the action potential to the triggering of secretory vesicle discharge. Calcium channels are positioned very close to the secretory vesicles so that when they open the spurt of entering calcium ions, called a ‘calcium domain’, can rapidly and effectively access the triggering sites for synaptic vesicle fusion." @default.
• W4254925344 created "2022-05-12" @default.
• W4254925344 creator A5052510554 @default.
• W4254925344 creator A5070771744 @default.
• W4254925344 date "2009-09-15" @default.
• W4254925344 modified "2023-09-29" @default.
• W4254925344 title "Calcium and Neurotransmitter Release" @default.
• W4254925344 cites W1520756199 @default.
• W4254925344 cites W1642181682 @default.
• W4254925344 cites W1798558936 @default.
• W4254925344 cites W1900274922 @default.
• W4254925344 cites W1904014509 @default.
• W4254925344 cites W1959896955 @default.
• W4254925344 cites W1969308562 @default.
• W4254925344 cites W1970849523 @default.
• W4254925344 cites W1972529694 @default.
• W4254925344 cites W1979381976 @default.
• W4254925344 cites W1980376542 @default.
• W4254925344 cites W1983820222 @default.
• W4254925344 cites W1988007470 @default.
• W4254925344 cites W1990220309 @default.
• W4254925344 cites W1992877229 @default.
• W4254925344 cites W1995528444 @default.
• W4254925344 cites W1996618398 @default.
• W4254925344 cites W2000817025 @default.
• W4254925344 cites W2001389730 @default.
• W4254925344 cites W2004597190 @default.
• W4254925344 cites W2007283243 @default.
• W4254925344 cites W2015011519 @default.
• W4254925344 cites W2018170523 @default.
• W4254925344 cites W2020686203 @default.
• W4254925344 cites W2021413809 @default.
• W4254925344 cites W2025724809 @default.
• W4254925344 cites W2030419485 @default.
• W4254925344 cites W2032258485 @default.
• W4254925344 cites W2035225641 @default.
• W4254925344 cites W2040477003 @default.
• W4254925344 cites W2040618621 @default.
• W4254925344 cites W2041101202 @default.
• W4254925344 cites W2042447398 @default.
• W4254925344 cites W2052960022 @default.
• W4254925344 cites W2072730361 @default.
• W4254925344 cites W2075183645 @default.
• W4254925344 cites W2076386790 @default.
• W4254925344 cites W2087758815 @default.
• W4254925344 cites W2090662268 @default.
• W4254925344 cites W2091194839 @default.
• W4254925344 cites W2093441174 @default.
• W4254925344 cites W2094930349 @default.
• W4254925344 cites W2098022672 @default.
• W4254925344 cites W2100446252 @default.
• W4254925344 cites W2101691189 @default.
• W4254925344 cites W2108270932 @default.
• W4254925344 cites W2112927743 @default.
• W4254925344 cites W2113671810 @default.
• W4254925344 cites W2117566528 @default.
• W4254925344 cites W2119063345 @default.
• W4254925344 cites W2122383890 @default.
• W4254925344 cites W2123091486 @default.
• W4254925344 cites W2125659451 @default.
• W4254925344 cites W2125877971 @default.
• W4254925344 cites W2126365527 @default.
• W4254925344 cites W2127431229 @default.
• W4254925344 cites W2128967907 @default.
• W4254925344 cites W2133673540 @default.
• W4254925344 cites W2142657247 @default.
• W4254925344 cites W2149394947 @default.
• W4254925344 cites W2158561409 @default.
• W4254925344 doi "https://doi.org/10.1002/9780470015902.a0000027.pub3" @default.
• W4254925344 hasPublicationYear "2009" @default.
• W4254925344 type Work @default.
• W4254925344 citedByCount "2" @default.
• W4254925344 countsByYear W42549253442016 @default.
• W4254925344 crossrefType "other" @default.
• W4254925344 hasAuthorship W4254925344A5052510554 @default.
• W4254925344 hasAuthorship W4254925344A5070771744 @default.
• W4254925344 hasConcept C12554922 @default.
• W4254925344 hasConcept C130316041 @default.
• W4254925344 hasConcept C148785051 @default.
• W4254925344 hasConcept C156927020 @default.
• W4254925344 hasConcept C169760540 @default.
• W4254925344 hasConcept C170493617 @default.
• W4254925344 hasConcept C178790620 @default.
• W4254925344 hasConcept C185592680 @default.
• W4254925344 hasConcept C18699975 @default.
• W4254925344 hasConcept C187102610 @default.
• W4254925344 hasConcept C197341189 @default.
• W4254925344 hasConcept C200170125 @default.
• W4254925344 hasConcept C2776219046 @default.
• W4254925344 hasConcept C2778794669 @default.
• W4254925344 hasConcept C2993285035 @default.
• W4254925344 hasConcept C41625074 @default.
• W4254925344 hasConcept C519063684 @default.
• W4254925344 hasConcept C529278444 @default.
• W4254925344 hasConcept C55493867 @default.
• W4254925344 hasConcept C86803240 @default.
• W4254925344 hasConceptScore W4254925344C12554922 @default.
• W4254925344 hasConceptScore W4254925344C130316041 @default.
• W4254925344 hasConceptScore W4254925344C148785051 @default.
• W4254925344 hasConceptScore W4254925344C156927020 @default.

• next