Matches in SemOpenAlex for { <https://semopenalex.org/work/W4254927354> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4254927354 endingPage "885" @default.
- W4254927354 startingPage "885" @default.
- W4254927354 abstract "Aplastic anemia (AA) is a rare hematopoietic stem-cell disorder that results in pancytopenia and hypocellular bone marrow. The pathophysiology of acquired AA is immune-mediated in most cases. Activated type 1 cytotoxic T cells mediate the destruction of hematopoietic stem cells. The aberrant immune response and deficiencies in hematopoietic cells is now elucidated by molecular studies. In recent days, either stem cell transplant or immunosuppressive drug therapy with better supportive care has greatly improved the outcomes of patients with otherwise fatal disease. Combined immunosuppression with antithymocyte globulins and cyclosporine are effective in restoring blood counts in the majority of patients, but relapse and clonal evolution remain problematic. Allogeneic stem cell transplantation from matched sibling donors is curative in the great majority of young patients with severe AA. However, the results in patients who are older or lack family donors have room for improvement. Recent transplant results from alternative donors using a variety of conditioning regimens to enhance engraftment have been promising, especially in certain pediatric series." @default.
- W4254927354 created "2022-05-12" @default.
- W4254927354 creator A5008938100 @default.
- W4254927354 date "2006-01-01" @default.
- W4254927354 modified "2023-09-27" @default.
- W4254927354 title "Aplastic Anemia" @default.
- W4254927354 cites W1502200885 @default.
- W4254927354 cites W1967949472 @default.
- W4254927354 cites W1969849446 @default.
- W4254927354 cites W1970972261 @default.
- W4254927354 cites W1971557056 @default.
- W4254927354 cites W1978462579 @default.
- W4254927354 cites W1987061419 @default.
- W4254927354 cites W1997651943 @default.
- W4254927354 cites W2023670986 @default.
- W4254927354 cites W2033498694 @default.
- W4254927354 cites W2036245297 @default.
- W4254927354 cites W2037546451 @default.
- W4254927354 cites W2037894368 @default.
- W4254927354 cites W2037921839 @default.
- W4254927354 cites W2043747739 @default.
- W4254927354 cites W2052285621 @default.
- W4254927354 cites W2054369619 @default.
- W4254927354 cites W2056235669 @default.
- W4254927354 cites W2057417956 @default.
- W4254927354 cites W2062188278 @default.
- W4254927354 cites W2073210769 @default.
- W4254927354 cites W2076005731 @default.
- W4254927354 cites W2080503635 @default.
- W4254927354 cites W2084968573 @default.
- W4254927354 cites W2085516849 @default.
- W4254927354 cites W2106456757 @default.
- W4254927354 cites W2115871172 @default.
- W4254927354 cites W2119566322 @default.
- W4254927354 cites W3146127625 @default.
- W4254927354 cites W4255204353 @default.
- W4254927354 doi "https://doi.org/10.5124/jkma.2006.49.10.885" @default.
- W4254927354 hasPublicationYear "2006" @default.
- W4254927354 type Work @default.
- W4254927354 citedByCount "1" @default.
- W4254927354 countsByYear W42549273542016 @default.
- W4254927354 crossrefType "journal-article" @default.
- W4254927354 hasAuthorship W4254927354A5008938100 @default.
- W4254927354 hasBestOaLocation W42549273541 @default.
- W4254927354 hasConcept C109159458 @default.
- W4254927354 hasConcept C114538912 @default.
- W4254927354 hasConcept C126322002 @default.
- W4254927354 hasConcept C203014093 @default.
- W4254927354 hasConcept C2777408962 @default.
- W4254927354 hasConcept C2778248108 @default.
- W4254927354 hasConcept C2779382419 @default.
- W4254927354 hasConcept C2780007613 @default.
- W4254927354 hasConcept C2780252810 @default.
- W4254927354 hasConcept C2780525284 @default.
- W4254927354 hasConcept C2781440808 @default.
- W4254927354 hasConcept C28328180 @default.
- W4254927354 hasConcept C2911091166 @default.
- W4254927354 hasConcept C54355233 @default.
- W4254927354 hasConcept C71924100 @default.
- W4254927354 hasConcept C86803240 @default.
- W4254927354 hasConcept C8891405 @default.
- W4254927354 hasConceptScore W4254927354C109159458 @default.
- W4254927354 hasConceptScore W4254927354C114538912 @default.
- W4254927354 hasConceptScore W4254927354C126322002 @default.
- W4254927354 hasConceptScore W4254927354C203014093 @default.
- W4254927354 hasConceptScore W4254927354C2777408962 @default.
- W4254927354 hasConceptScore W4254927354C2778248108 @default.
- W4254927354 hasConceptScore W4254927354C2779382419 @default.
- W4254927354 hasConceptScore W4254927354C2780007613 @default.
- W4254927354 hasConceptScore W4254927354C2780252810 @default.
- W4254927354 hasConceptScore W4254927354C2780525284 @default.
- W4254927354 hasConceptScore W4254927354C2781440808 @default.
- W4254927354 hasConceptScore W4254927354C28328180 @default.
- W4254927354 hasConceptScore W4254927354C2911091166 @default.
- W4254927354 hasConceptScore W4254927354C54355233 @default.
- W4254927354 hasConceptScore W4254927354C71924100 @default.
- W4254927354 hasConceptScore W4254927354C86803240 @default.
- W4254927354 hasConceptScore W4254927354C8891405 @default.
- W4254927354 hasIssue "10" @default.
- W4254927354 hasLocation W42549273541 @default.
- W4254927354 hasOpenAccess W4254927354 @default.
- W4254927354 hasPrimaryLocation W42549273541 @default.
- W4254927354 hasRelatedWork W2032257399 @default.
- W4254927354 hasRelatedWork W2058912799 @default.
- W4254927354 hasRelatedWork W2067301395 @default.
- W4254927354 hasRelatedWork W2068124243 @default.
- W4254927354 hasRelatedWork W2125645556 @default.
- W4254927354 hasRelatedWork W2593634284 @default.
- W4254927354 hasRelatedWork W2799746593 @default.
- W4254927354 hasRelatedWork W4226199187 @default.
- W4254927354 hasRelatedWork W4230817393 @default.
- W4254927354 hasRelatedWork W4293019142 @default.
- W4254927354 hasVolume "49" @default.
- W4254927354 isParatext "false" @default.
- W4254927354 isRetracted "false" @default.
- W4254927354 workType "article" @default.