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- W4254964914 abstract "Topiramate is a new antiepileptic drug that has been approved for use in epilepsy by the regulatory authorities of many countries as adjunctive treatment for partial seizures whether or not they become secondarily generalized, for seizures associated with the Lennox-Gastaut syndrome and for primary generalized tonic-clonic seizures. Recent studies have described topiramate’s pharmacodynamic profile and have demonstrated that its antiepileptic action may be a result of several mechanisms including effects on sodium and potassium channels, a novel interaction with the GABAA receptor and inhibition of the action of kainate on the kainate/AMPA subtype of glutamate receptor.KeywordsAntiepileptic DrugGABAA ReceptorSeizure FrequencyPartial Onset SeizureCentral Nervous System Side EffectThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W4254964914 date "1999-01-01" @default.
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- W4254964914 title "Topiramate" @default.
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- W4254964914 doi "https://doi.org/10.1007/978-3-642-60072-2_18" @default.
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