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- W4255011984 abstract "This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The objective of this review is to test the hypothesis that intravenous steroid treatment and oral steroid treatment in the context of acute MS relapses are equally efficacious and safe. The following is a detailed list of objectives for this review: Primary Objective To determine if there is a difference in efficacy with respect to the degree of clinical relapse recovery between oral an intravenous steroid treatment given at the time of relapse in patients with a diagnosis of Multiple Sclerosis. Secondary Objectives 1. To examine the need for retreatment of relapse event 2. To measure the subsequent relapses rate, timing and disability 3. To assess the nature and frequency of adverse events ranging from minor to serious 4. To measure the direct and indirect cost of the relapse event monetarily and in service demand and lost productivity 5. To assess the need for hospitalization 6. To measure quality of life 7. To evaluate the bioavailability of the different steroid routes of administration 8. To measure the change and presence of immunological markers 9. To measure the change and presence of MRI lesions of the CNS" @default.
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- W4255011984 date "2008-01-23" @default.
- W4255011984 modified "2023-09-24" @default.
- W4255011984 title "Oral versus Intravenous Steroids for Treatment of Relapses in Multiple Sclerosis" @default.
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- W4255011984 doi "https://doi.org/10.1002/14651858.cd006921" @default.
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