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- W4255018889 abstract "The serum antibodies to N-acetylgalactosaminyl GD1a (GalNAc-GD1a) and other gangliosides as well as to Campylobacter jejuni were determined in 147 patients with Guillain-Barré syndrome (GBS). We found a distinctive clinical pattern in patients with anti-GalNAc-GD1a antibodies compared with those without the antibodies, that is, lack of cranial nerve involvement (87% versus 38%), distal-dominant weakness (80% versus 25%), and no sensory disturbance (73% versus 22%). The frequency of distal-dominant weakness was significantly higher in patients with both C jejuni infection and anti-GalNAc-GD1a positivity (100%) than in C jejuni–negative/anti-GalNAc-GD1a–positive (25%), C jejuni–positive/anti-GalNAc-GD1a–negative (32%) and C jejuni–negative/anti-GalNAc-GD1a–negative patients (20%). Lack of cranial nerve involvement and sensory disturbance were found in most C jejuni–positive/anti-GalNAc-GD1a–positive and C jejuni–negative/anti-GalNAc-GD1a–positive patients, but not in C jejuni–positive/anti-GalNAc-GD1a–negative and C jejuni–negative/anti-GalNAc-GD1a–negative patients. Although the anti-GM1–positive/anti-GalNAc-GD1a–negative patients mostly (75%) lacked cranial nerve involvement, distal-dominant weakness (38%) and lack of sensory disturbance (13%) were infrequent. These results may indicate that (1) the combination of C jejuni infection and anti-GalNAc-GD1a antibodies, but not anti-GalNAc-GD1a, anti-GM1, or C jejuni infection alone, is associated with a predominantly distal weakness, (2) the presence of anti-GalNAc-GD1a, rather than C jejuni infection or anti-GM1 antibody, is associated with a lack of sensory disturbance, (3) both anti-GalNAc-GD1a and anti-GM1 antibodies are independently associated with a lack of cranial nerve impairment. Ann Neurol 1999;45:758–768" @default.
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- W4255018889 date "1999-06-01" @default.
- W4255018889 modified "2023-09-23" @default.
- W4255018889 title "Anti‐GalNAc‐GD1a antibody–associated Guillain‐Barré syndrome with a predominantly distal weakness without cranial nerve impairment and sensory disturbance" @default.
- W4255018889 doi "https://doi.org/10.1002/1531-8249(199906)45:6<758::aid-ana10>3.3.co;2-e" @default.
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