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- W4255024055 abstract "Phosphorus (P) is present in diets either as naturally occurring P from raw materials or added as an inorganic salt, however little is known about postprandial kinetics of P absorption in cats. Here we describe several studies quantifying postprandial kinetics following the ingestion of diets of varying composition. Briefly, cats were fed a meal consisting of 50% of their metabolic energy requirement in a randomized crossover design. A pre-meal baseline blood sample was taken via cephalic catheter and repeated measurements taken regularly up to 6h post meal to assess whole blood ionized calcium, plasma P and parathyroid hormone (PTH) concentrations. A diet containing total P 4.8g/1000kcal, sodium dihydrogen phosphate (SDHP, NaH2PO4) 3.5g/1000kcal, Ca:P 0.54 caused a marked increase in plasma P from baseline to a peak of 1.976 mmol/L with 95% confidence interval (1.724, 2.266), p<0.001, whereas a diet containing total P 3.38g/1000kcal, no added inorganic P, Ca:P 1.55 resulted in a postprandial decrease in plasma P (p=0.008). Subsequent data indicate that added inorganic P in the diet (above 0.5g/1000kcal) causes an increase in plasma P in cats while diets with low added inorganic P inclusion (0.5g/1000kcal and below) do not display this response. The data presented here demonstrate that sources of added inorganic P cause a temporary postprandial increase in plasma P in a dose-dependent manner, prolonged in diets with a Ca:P less than 1.0. Dietary P derived from natural food ingredients (e.g. meat or vegetable matter) does not appear to have any effect on postprandial plasma P." @default.
- W4255024055 created "2022-05-12" @default.
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- W4255024055 date "2018-05-18" @default.
- W4255024055 modified "2023-10-16" @default.
- W4255024055 title "kinetic manuscript" @default.
- W4255024055 doi "https://doi.org/10.31219/osf.io/reahy" @default.
- W4255024055 hasPublicationYear "2018" @default.
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