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• W4255047390 abstract "Functional MRI (fMRI) studies have reported paradoxical posterior cingulate cortex (PCC) preservation in Mild Cognitive Impairment (MCI) patients when performing a self-reference task[1]. It is still unknown however whether this preserved PCC activity is an early phenomenon that remains stable despite severe metabolic and structural PCC alterations occurring in the course of Alzheimer's disease (AD)[2]. The aim of the present study was to address this question by measuring PCC activity during a self-referential task together with PCC volume and metabolism in the same demented AD patients. Six AD patients and 12 healthy controls (HC) matched for age, sex and education, all from the IMAP project, were included in these preliminary analyses. All participants underwent a self-referential fMRI session[3]-[6], a T1-MRI acquisition and a FDG-PET scan. Data were transformed in comparable parametric maps after correction for geometrical distortions[3] and partial volume effects[7]. Self-Referential BOLD response was then assessed using voxelwise statistics. PCC values were finally extracted from the three neuroimaging datasets and values of each patient were z-score transformed using the corresponding values of the controls[8]. All PCC statistics were performed using non-parametric tests. Both HC and AD showed significant voxelwise self-referential BOLD activations in a large network including the PCC with no significant difference between the two groups. As compared to controls, AD patients showed a significant PCC FDG-PET hypometabolism and a trend for PCC atrophy (p = 0.097), while there was no difference in PCC Self-Referential BOLD response magnitude. The repeated-measures ANOVA performed on the three neuroimaging modality z-scores was significant (Figure 1). Paired t-tests revealed that FDG-PET PCC Z-scores were significantly more negative than both the PCC volume and Self-Referential BOLD response z-scores, as well as a trend for more negative z-scores for PCC volume than PCC Self-Referential BOLD response (p = 0.093) (Figure 1)." @default.
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• W4255047390 date "2011-07-01" @default.
• W4255047390 modified "2023-09-30" @default.
• W4255047390 title "P4-117: The IMAP project - The paradox of the posterior cingulate cortex in Alzheimer's disease: Atrophic, hypometabolic, but still able to show preserved fMRI activity during a self-related task" @default.
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• W4255047390 doi "https://doi.org/10.1016/j.jalz.2011.05.2138" @default.
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