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- W4255055275 abstract "We describe a method for quantitating heterogeneity in the rate of benzo[ a ]pyrene metabolism in single cells by using flow cytometry. We have used the technique to study the response of Hepa-1c1c7 mouse hepatoma cells to the microsomal enzyme inducer 2,3,7,8-tetrachlorodibenzo- p -dioxin. Cells responded in a relatively homogeneous fashion at different times of induction with a maximally inducing concentration of the inducer. However, the induction response could be heterogeneous at a submaximal inducer concentration. We found even higher heterogeneity of enzyme activity among low-activity variants derived from the Hepa-1c1c7 cell line. When cells of either high or low activity were isolated from such a clonal population, propagated, and reanalyzed, they displayed average enzyme activity and heterogeneity identical to the parental cells; therefore, the heterogeneity represents transient, nonheritable differences between cells within the population." @default.
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- W4255055275 date "1982-06-01" @default.
- W4255055275 modified "2023-10-17" @default.
- W4255055275 title "Heterogeneity in the Rate of Benzo[ a ]pyrene Metabolism in Single Cells: Quantitation Using Flow Cytometry" @default.
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- W4255055275 doi "https://doi.org/10.1128/mcb.2.6.625-632.1982" @default.
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