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- W4255060963 abstract "This chapter provides basic characteristics, FDA-approved indications, side effects/toxicity, dosage information, drug/food interactions and antimicrobial therapy art of SOVALDI (sofosbuvir). Sofosbuvir undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate, which can be incorporated into hepatitis C virus (HCV) RNA by the NS5B polymerase and acts as a chain terminator. Sofosbuvir is indicated for the treatment of genotype 1, 2, 3, or 4 chronic HCV infection as a component of a combination antiviral treatment regimen. One 400 mg tablet, taken orally, once daily with or without food. Patients taking beta-blockers, or those with underlying cardiac comorbidities and/or advanced liver disease, may be at increased risk for symptomatic bradycardia with coadministration of sofosbuvir and amiodarone. Sofosbuvir in combination with ribavirin for 24 weeks can be considered as a therapeutic option for patients with genotype 1 infection who are ineligible to receive an interferon-based regimen. Sofosbuvir can be used in HIV coinfected patients." @default.
- W4255060963 created "2022-05-12" @default.
- W4255060963 date "2017-08-30" @default.
- W4255060963 modified "2023-10-17" @default.
- W4255060963 title "SOVALDI (Sofosbuvir)" @default.
- W4255060963 doi "https://doi.org/10.1002/9781119220787.ch156" @default.
- W4255060963 hasPublicationYear "2017" @default.
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