Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255087136> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4255087136 endingPage "vii" @default.
- W4255087136 startingPage "vii" @default.
- W4255087136 abstract "Pharmacokinetic studies demonstrated the advantage of intraperitoneal oxaliplatin (1-OHP) for cancers restricted to the peritoneal cavity. The area under the concentration × time curve (AUC) in the peritoneal cavity for both total and ultrafiltered drug was almost 2 times higher for 1-OHP than cisplatin (cDDP). The AUC for ultrafiltered 1-OHP in plasma was also a factor 4 higher than cDDP, indicating that peritoneal tumors received a higher exposure from 1-OHP than cDDP directly in the peritoneal cavity and indirectly via the systemic circulation.Total platinum concentrations in peritoneal tumors of rats were determined after i.p. administration of equimolar doses of 1-OHP and cDDP. In spite of the pharmacological advantages, no significant difference in platinum concentration was demonstrated. In addition, no difference in the distribution of platinum within peritoneal tumors was detected after i.p. treatment with equimolar doses, i.e., platinum concentrations were comparable both in the periphery, 29 ± 4 ppm for cDDP and 22 ± 8 for 1-OHP and in the center of the tumor, 18 ± 3 for both drugs.When CC531 tumor cells were incubated in vitro with equimolar concentrations of 1-DHP and cDDP in vitro, 2 to 4 times less platinum was found in cells treated with 1-OHP, indicating that the uptake of 1-OHP differed from that of cDDP. Oxaliplatin was not cross resistant for cDDP in CC531.RL4 tumor cells, a cDDP resistant cell line, which may indicate its value in ovarian cancer patients who did not respond to earlier cDDP treatment." @default.
- W4255087136 created "2022-05-12" @default.
- W4255087136 date "1985-01-01" @default.
- W4255087136 modified "2023-09-25" @default.
- W4255087136 title "4450146 heat recovery in P2O5 production process" @default.
- W4255087136 doi "https://doi.org/10.1016/0198-7593(85)90148-1" @default.
- W4255087136 hasPublicationYear "1985" @default.
- W4255087136 type Work @default.
- W4255087136 citedByCount "0" @default.
- W4255087136 crossrefType "journal-article" @default.
- W4255087136 hasConcept C112705442 @default.
- W4255087136 hasConcept C121608353 @default.
- W4255087136 hasConcept C126322002 @default.
- W4255087136 hasConcept C141071460 @default.
- W4255087136 hasConcept C161790260 @default.
- W4255087136 hasConcept C185592680 @default.
- W4255087136 hasConcept C202751555 @default.
- W4255087136 hasConcept C2776694085 @default.
- W4255087136 hasConcept C2778239845 @default.
- W4255087136 hasConcept C2778536324 @default.
- W4255087136 hasConcept C2780427987 @default.
- W4255087136 hasConcept C2780962732 @default.
- W4255087136 hasConcept C518104683 @default.
- W4255087136 hasConcept C526805850 @default.
- W4255087136 hasConcept C55493867 @default.
- W4255087136 hasConcept C71924100 @default.
- W4255087136 hasConcept C98274493 @default.
- W4255087136 hasConceptScore W4255087136C112705442 @default.
- W4255087136 hasConceptScore W4255087136C121608353 @default.
- W4255087136 hasConceptScore W4255087136C126322002 @default.
- W4255087136 hasConceptScore W4255087136C141071460 @default.
- W4255087136 hasConceptScore W4255087136C161790260 @default.
- W4255087136 hasConceptScore W4255087136C185592680 @default.
- W4255087136 hasConceptScore W4255087136C202751555 @default.
- W4255087136 hasConceptScore W4255087136C2776694085 @default.
- W4255087136 hasConceptScore W4255087136C2778239845 @default.
- W4255087136 hasConceptScore W4255087136C2778536324 @default.
- W4255087136 hasConceptScore W4255087136C2780427987 @default.
- W4255087136 hasConceptScore W4255087136C2780962732 @default.
- W4255087136 hasConceptScore W4255087136C518104683 @default.
- W4255087136 hasConceptScore W4255087136C526805850 @default.
- W4255087136 hasConceptScore W4255087136C55493867 @default.
- W4255087136 hasConceptScore W4255087136C71924100 @default.
- W4255087136 hasConceptScore W4255087136C98274493 @default.
- W4255087136 hasIssue "1" @default.
- W4255087136 hasLocation W42550871361 @default.
- W4255087136 hasOpenAccess W4255087136 @default.
- W4255087136 hasPrimaryLocation W42550871361 @default.
- W4255087136 hasRelatedWork W1612745887 @default.
- W4255087136 hasRelatedWork W1965889589 @default.
- W4255087136 hasRelatedWork W1979295668 @default.
- W4255087136 hasRelatedWork W1990863288 @default.
- W4255087136 hasRelatedWork W2057051402 @default.
- W4255087136 hasRelatedWork W2075010434 @default.
- W4255087136 hasRelatedWork W2090114619 @default.
- W4255087136 hasRelatedWork W2102946399 @default.
- W4255087136 hasRelatedWork W2778342244 @default.
- W4255087136 hasRelatedWork W3000011530 @default.
- W4255087136 hasVolume "5" @default.
- W4255087136 isParatext "false" @default.
- W4255087136 isRetracted "false" @default.
- W4255087136 workType "article" @default.