FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255103633> ?p ?o ?g. }

• W4255103633 endingPage "1934578X1400900" @default.
• W4255103633 startingPage "1934578X1400900" @default.
• W4255103633 abstract "Flavonoids have been shown to be cytotoxic to cancer cells. However, the mechanism of cytotoxicity has not been clearly defined. It has previously been reported that HER2/ERBB2, the estrogen receptor, progesterone receptor, and p53 were required for flavonoid induced cytotoxicity in breast cancer cell lines. We have used a panel of breast cancer cell lines, known to contain as well as be deficient in these signaling pathways, to screen fourteen different flavonoids. Comparing the cytotoxicity for all flavonoids allows us to determine if a structure-functional relationship exists between cytotoxicity and flavonoid, and if a particular signaling pathway is required for cytotoxicity. We show that several flavonoids are cytotoxic to all cell lines including primary mammary epithelial cells tested. The cytotoxic flavonoids are also able to inhibit Mitochondrial Outer Membrane Permeability while at the same time stimulate ATP levels whereas the non-cytotoxic flavonoids are not able to do this. We also show that both cytotoxic and non-cytotoxic flavonoids can transverse the cell membrane to enter MDA-MB-231 cells at different levels. Finally, all flavonoids regardless of their cytotoxicity were able to induce some form of cell cycle arrest. We conclude that for flavonoids to be strongly cytotoxic, they must possess the 2,3-double bond in the C-ring and we believe the cytotoxicity occurs through mitochondrial poisoning in both cancer and normal cells." @default.
• W4255103633 created "2022-05-12" @default.
• W4255103633 creator A5020200300 @default.
• W4255103633 creator A5022735353 @default.
• W4255103633 creator A5041984228 @default.
• W4255103633 creator A5044984046 @default.
• W4255103633 creator A5056877366 @default.
• W4255103633 creator A5058668236 @default.
• W4255103633 creator A5061710991 @default.
• W4255103633 creator A5090550645 @default.
• W4255103633 creator A5090669312 @default.
• W4255103633 date "2014-05-01" @default.
• W4255103633 modified "2023-09-26" @default.
• W4255103633 title "Profiling Flavonoid Cytotoxicity in Human Breast Cancer Cell Lines: Determination of Structure-Function Relationships" @default.
• W4255103633 cites W1872501806 @default.
• W4255103633 cites W1976932448 @default.
• W4255103633 cites W1981488936 @default.
• W4255103633 cites W1983824549 @default.
• W4255103633 cites W1984833201 @default.
• W4255103633 cites W1990218909 @default.
• W4255103633 cites W1990979855 @default.
• W4255103633 cites W1991894742 @default.
• W4255103633 cites W1992629857 @default.
• W4255103633 cites W1997437309 @default.
• W4255103633 cites W2000137515 @default.
• W4255103633 cites W2002801265 @default.
• W4255103633 cites W2019050729 @default.
• W4255103633 cites W2022532937 @default.
• W4255103633 cites W2029433783 @default.
• W4255103633 cites W2032304812 @default.
• W4255103633 cites W2035364729 @default.
• W4255103633 cites W2037719603 @default.
• W4255103633 cites W2041958838 @default.
• W4255103633 cites W2042514640 @default.
• W4255103633 cites W2052728502 @default.
• W4255103633 cites W2052755516 @default.
• W4255103633 cites W2054073095 @default.
• W4255103633 cites W2062590377 @default.
• W4255103633 cites W2072698554 @default.
• W4255103633 cites W2073613078 @default.
• W4255103633 cites W2077749339 @default.
• W4255103633 cites W2078166953 @default.
• W4255103633 cites W2079130906 @default.
• W4255103633 cites W2092864619 @default.
• W4255103633 cites W2098588686 @default.
• W4255103633 cites W2135708499 @default.
• W4255103633 cites W2141692684 @default.
• W4255103633 cites W2142739240 @default.
• W4255103633 cites W2153939259 @default.
• W4255103633 cites W2160056300 @default.
• W4255103633 cites W2160615487 @default.
• W4255103633 cites W2169921289 @default.
• W4255103633 cites W2318098003 @default.
• W4255103633 doi "https://doi.org/10.1177/1934578x1400900501" @default.
• W4255103633 hasPublicationYear "2014" @default.
• W4255103633 type Work @default.
• W4255103633 citedByCount "2" @default.
• W4255103633 countsByYear W42551036332020 @default.
• W4255103633 countsByYear W42551036332021 @default.
• W4255103633 crossrefType "journal-article" @default.
• W4255103633 hasAuthorship W4255103633A5020200300 @default.
• W4255103633 hasAuthorship W4255103633A5022735353 @default.
• W4255103633 hasAuthorship W4255103633A5041984228 @default.
• W4255103633 hasAuthorship W4255103633A5044984046 @default.
• W4255103633 hasAuthorship W4255103633A5056877366 @default.
• W4255103633 hasAuthorship W4255103633A5058668236 @default.
• W4255103633 hasAuthorship W4255103633A5061710991 @default.
• W4255103633 hasAuthorship W4255103633A5090550645 @default.
• W4255103633 hasAuthorship W4255103633A5090669312 @default.
• W4255103633 hasBestOaLocation W42551036331 @default.
• W4255103633 hasConcept C109316439 @default.
• W4255103633 hasConcept C121608353 @default.
• W4255103633 hasConcept C154317977 @default.
• W4255103633 hasConcept C185592680 @default.
• W4255103633 hasConcept C190283241 @default.
• W4255103633 hasConcept C202751555 @default.
• W4255103633 hasConcept C502942594 @default.
• W4255103633 hasConcept C530470458 @default.
• W4255103633 hasConcept C54355233 @default.
• W4255103633 hasConcept C55493867 @default.
• W4255103633 hasConcept C81885089 @default.
• W4255103633 hasConcept C84606932 @default.
• W4255103633 hasConcept C86803240 @default.
• W4255103633 hasConcept C96232424 @default.
• W4255103633 hasConcept C98274493 @default.
• W4255103633 hasConceptScore W4255103633C109316439 @default.
• W4255103633 hasConceptScore W4255103633C121608353 @default.
• W4255103633 hasConceptScore W4255103633C154317977 @default.
• W4255103633 hasConceptScore W4255103633C185592680 @default.
• W4255103633 hasConceptScore W4255103633C190283241 @default.
• W4255103633 hasConceptScore W4255103633C202751555 @default.
• W4255103633 hasConceptScore W4255103633C502942594 @default.
• W4255103633 hasConceptScore W4255103633C530470458 @default.
• W4255103633 hasConceptScore W4255103633C54355233 @default.
• W4255103633 hasConceptScore W4255103633C55493867 @default.
• W4255103633 hasConceptScore W4255103633C81885089 @default.
• W4255103633 hasConceptScore W4255103633C84606932 @default.
• W4255103633 hasConceptScore W4255103633C86803240 @default.

• next