FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255127524> ?p ?o ?g. }

• W4255127524 abstract "Abstract Purpose: To compare long-term disease-related outcomes and late radiation morbidity between intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) in head and neck squamous cell carcinoma (HNSCC) in the setting of a prospective randomized controlled trial. Methods: Previously untreated patients with early to moderately advanced non-metastatic squamous carcinoma of the oropharynx, larynx, or hypopharynx (T1-T3, N0-N2b, M0) planned for comprehensive irradiation of primary site and bilateral neck nodes were randomly assigned to either IMRT or 3D-CRT after written informed consent. Patients were treated with 6MV photons to a total dose of 70Gy/35 fractions over 7 weeks (3D-CRT) or 66Gy/30 fractions over 6 weeks (IMRT). A sample size of 60 patients was estimated to demonstrate 35% absolute difference in the incidence of ≥grade 2 acute xerostomia between the two arms. All time-to-event outcomes were calculated from date of randomization until the defined event using the Kaplan-Meier method. Results: At a median follow-up of 140 months for surviving patients, 10-year Kaplan-Meier estimates of loco-regional control (LRC); progression-free survival (PFS); and overall survival (OS) with 95% confidence interval (95%CI) were 73.6% (95%CI: 61.2-86%); 45.2% (95%CI: 32-58.4%); and 50.3% (95%CI: 37.1-63.5%) respectively. There were no significant differences in 10-year disease-related outcomes between 3D-CRT and IMRT for LRC [79.2% (95%CI: 62.2-96.2%) vs 68.7% (95%CI: 51.1-86.3%), p=0.39]; PFS [41.3% (95%CI: 22.3-60.3%) vs 48.6% (95%CI: 30.6-66.6%), p=0.59]; or OS [44.9% (95%CI: 25.7-64.1%) vs 55.0% (95%CI: 37-73%), p=0.49]. Significantly lesser proportion of patients in the IMRT arm experienced ≥grade 2 late xerostomia and subcutaneous fibrosis at all time-points. However, at longer follow-up, fewer patients remained evaluable for late radiation toxicity reducing statistical power and precision. Conclusions: IMRT provides a clinically meaningful and sustained reduction in the incidence of moderate to severe xerostomia and subcutaneous fibrosis compared to 3D-CRT without compromising disease-related outcomes in long-term survivors of non-nasopharyngeal HNSCC." @default.
• W4255127524 created "2022-05-12" @default.
• W4255127524 creator A5014065182 @default.
• W4255127524 creator A5027402189 @default.
• W4255127524 creator A5035337308 @default.
• W4255127524 creator A5041957465 @default.
• W4255127524 creator A5043387441 @default.
• W4255127524 creator A5045677912 @default.
• W4255127524 creator A5058486522 @default.
• W4255127524 creator A5061619941 @default.
• W4255127524 creator A5090197229 @default.
• W4255127524 date "2020-08-28" @default.
• W4255127524 modified "2023-09-24" @default.
• W4255127524 title "Intensity-modulated radiation therapy versus three-dimensional conformal radiotherapy in head and neck squamous cell carcinoma: long-term and mature outcomes of a prospective randomized trial" @default.
• W4255127524 doi "https://doi.org/10.21203/rs.3.rs-42435/v2" @default.
• W4255127524 hasPublicationYear "2020" @default.
• W4255127524 type Work @default.
• W4255127524 citedByCount "0" @default.
• W4255127524 crossrefType "posted-content" @default.
• W4255127524 hasAuthorship W4255127524A5014065182 @default.
• W4255127524 hasAuthorship W4255127524A5027402189 @default.
• W4255127524 hasAuthorship W4255127524A5035337308 @default.
• W4255127524 hasAuthorship W4255127524A5041957465 @default.
• W4255127524 hasAuthorship W4255127524A5043387441 @default.
• W4255127524 hasAuthorship W4255127524A5045677912 @default.
• W4255127524 hasAuthorship W4255127524A5058486522 @default.
• W4255127524 hasAuthorship W4255127524A5061619941 @default.
• W4255127524 hasAuthorship W4255127524A5090197229 @default.
• W4255127524 hasBestOaLocation W42551275241 @default.
• W4255127524 hasConcept C126322002 @default.
• W4255127524 hasConcept C141071460 @default.
• W4255127524 hasConcept C143998085 @default.
• W4255127524 hasConcept C168563851 @default.
• W4255127524 hasConcept C188816634 @default.
• W4255127524 hasConcept C204243189 @default.
• W4255127524 hasConcept C2776530083 @default.
• W4255127524 hasConcept C2776833033 @default.
• W4255127524 hasConcept C2780474809 @default.
• W4255127524 hasConcept C2989005 @default.
• W4255127524 hasConcept C44249647 @default.
• W4255127524 hasConcept C509974204 @default.
• W4255127524 hasConcept C71924100 @default.
• W4255127524 hasConceptScore W4255127524C126322002 @default.
• W4255127524 hasConceptScore W4255127524C141071460 @default.
• W4255127524 hasConceptScore W4255127524C143998085 @default.
• W4255127524 hasConceptScore W4255127524C168563851 @default.
• W4255127524 hasConceptScore W4255127524C188816634 @default.
• W4255127524 hasConceptScore W4255127524C204243189 @default.
• W4255127524 hasConceptScore W4255127524C2776530083 @default.
• W4255127524 hasConceptScore W4255127524C2776833033 @default.
• W4255127524 hasConceptScore W4255127524C2780474809 @default.
• W4255127524 hasConceptScore W4255127524C2989005 @default.
• W4255127524 hasConceptScore W4255127524C44249647 @default.
• W4255127524 hasConceptScore W4255127524C509974204 @default.
• W4255127524 hasConceptScore W4255127524C71924100 @default.
• W4255127524 hasLocation W42551275241 @default.
• W4255127524 hasLocation W42551275242 @default.
• W4255127524 hasLocation W42551275243 @default.
• W4255127524 hasOpenAccess W4255127524 @default.
• W4255127524 hasPrimaryLocation W42551275241 @default.
• W4255127524 hasRelatedWork W11093380 @default.
• W4255127524 hasRelatedWork W14757395 @default.
• W4255127524 hasRelatedWork W15112652 @default.
• W4255127524 hasRelatedWork W3067138 @default.
• W4255127524 hasRelatedWork W4408631 @default.
• W4255127524 hasRelatedWork W4527439 @default.
• W4255127524 hasRelatedWork W4907272 @default.
• W4255127524 hasRelatedWork W7679475 @default.
• W4255127524 hasRelatedWork W8337555 @default.
• W4255127524 hasRelatedWork W8454978 @default.
• W4255127524 isParatext "false" @default.
• W4255127524 isRetracted "false" @default.
• W4255127524 workType "article" @default.