Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255137130> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W4255137130 endingPage "IV" @default.
- W4255137130 startingPage "I" @default.
- W4255137130 abstract "The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, while no treatment has been proven effective. COVID-19 pathophysiology involves the activation of three main pathways: the inflammatory, the coagulation and the bradykinin cascades. Here, we highlight for the first time the joint potential therapeutic role of bromelain and curcumin, two well-known nutraceuticals, in the prevention of severe COVID-19. Bromelain (a cysteine protease isolated from the pineapple stem) and curcumin (a natural phenol found in turmeric) exert important immunomodulatory actions interfering in the crucial steps of COVID-19 pathophysiology. Their anti-inflammatory properties include inhibition of transcription factors and subsequent downregulation of proinflammatory mediators. They also present fibrinolytic and anticoagulant properties. Additionally, bromelain inhibits cyclooxygenase and modulates prostaglandins and thromboxane, affecting both inflammation and coagulation, and also hydrolyzes bradykinin. Interestingly, curcumin has been shown in silico studies to prevent entry of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells as well as viral replication, while a recent experimental study has demonstrated that bromelain may also inhibit viral entry into cells. Notably, bromelain substantially increases the absorption of curcumin after oral administration. To the best of our knowledge, this is the first report highlighting the significance of bromelain and, most importantly, the potential preventive value of the synergistic effects of bromelain and curcumin against severe COVID-19." @default.
- W4255137130 created "2022-05-12" @default.
- W4255137130 date "2000-12-01" @default.
- W4255137130 modified "2023-09-26" @default.
- W4255137130 title "Museum Management and Curatorship" @default.
- W4255137130 doi "https://doi.org/10.1016/s0260-4779(01)00023-1" @default.
- W4255137130 hasPublicationYear "2000" @default.
- W4255137130 type Work @default.
- W4255137130 citedByCount "0" @default.
- W4255137130 crossrefType "journal-article" @default.
- W4255137130 hasConcept C164027704 @default.
- W4255137130 hasConcept C170493617 @default.
- W4255137130 hasConcept C181199279 @default.
- W4255137130 hasConcept C185592680 @default.
- W4255137130 hasConcept C203014093 @default.
- W4255137130 hasConcept C2776714187 @default.
- W4255137130 hasConcept C2776914184 @default.
- W4255137130 hasConcept C2777334355 @default.
- W4255137130 hasConcept C2778250585 @default.
- W4255137130 hasConcept C2779591629 @default.
- W4255137130 hasConcept C55493867 @default.
- W4255137130 hasConcept C71924100 @default.
- W4255137130 hasConcept C98274493 @default.
- W4255137130 hasConceptScore W4255137130C164027704 @default.
- W4255137130 hasConceptScore W4255137130C170493617 @default.
- W4255137130 hasConceptScore W4255137130C181199279 @default.
- W4255137130 hasConceptScore W4255137130C185592680 @default.
- W4255137130 hasConceptScore W4255137130C203014093 @default.
- W4255137130 hasConceptScore W4255137130C2776714187 @default.
- W4255137130 hasConceptScore W4255137130C2776914184 @default.
- W4255137130 hasConceptScore W4255137130C2777334355 @default.
- W4255137130 hasConceptScore W4255137130C2778250585 @default.
- W4255137130 hasConceptScore W4255137130C2779591629 @default.
- W4255137130 hasConceptScore W4255137130C55493867 @default.
- W4255137130 hasConceptScore W4255137130C71924100 @default.
- W4255137130 hasConceptScore W4255137130C98274493 @default.
- W4255137130 hasIssue "4" @default.
- W4255137130 hasLocation W42551371301 @default.
- W4255137130 hasOpenAccess W4255137130 @default.
- W4255137130 hasPrimaryLocation W42551371301 @default.
- W4255137130 hasRelatedWork W1987868998 @default.
- W4255137130 hasRelatedWork W2104785350 @default.
- W4255137130 hasRelatedWork W2133765154 @default.
- W4255137130 hasRelatedWork W2147463626 @default.
- W4255137130 hasRelatedWork W2165578318 @default.
- W4255137130 hasRelatedWork W2313033156 @default.
- W4255137130 hasRelatedWork W2748952813 @default.
- W4255137130 hasRelatedWork W2899084033 @default.
- W4255137130 hasRelatedWork W2911759928 @default.
- W4255137130 hasRelatedWork W4317107607 @default.
- W4255137130 hasVolume "18" @default.
- W4255137130 isParatext "false" @default.
- W4255137130 isRetracted "false" @default.
- W4255137130 workType "article" @default.