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- W4255176568 abstract "To assess the effect of maternal breast milk supplementation on the development of exclusively breast‐fed very low birth weight preterm infants at 12 months of corrected age. A randomized clinical trial with 53 infants followed‐up after discharge from the neonatal unit until a corrected gestational age of 12 months. Newborns in the intervention group were breastfed exclusively with maternal milk and received 2 g of a multinutrient supplement (Pré‐Nan®, Nestlé, Vevey, Switzerland) added to expressed breast milk twice a day until a corrected age of 4 to 6 months. The control group was exclusively breastfed without supplementation. After monthly follow‐up, developmental assessment was performed using the Bayley III Scale. There was no statistically significant difference on the Bayley III Scale between the intervention and control groups in any of the assessed domains: motor, cognitive, and communication. However, scores in the three domains were always higher in the group that received the supplement. There were a similar number of cases of developmental delay in both groups: seven (28%) in the group that received the supplement and nine (33.3%) in the group that was exclusively breastfed. The results failed to show an association between post‐discharge multinutrient supplementation and development in the assessed infants. Avaliar o efeito da suplementação do aleitamento materno exclusivo com aditivo multicomponente no desenvolvimento de lactentes nascidos pré‐termo de muito baixo peso aos 12 meses de idade gestacional corrigida. Ensaio clínico randomizado com 53 lactentes, acompanhados da alta hospitalar na Unidade Neonatal até o 12° mês de idade gestacional corrigida. Aqueles alocados no grupo intervenção permaneciam em aleitamento materno exclusivo e recebiam dois gramas de suplemento multicomponente em pó (Pré‐Nan®, Nestlé, Vevey, Suíça), adicionados ao leite ordenhado duas vezes ao dia, por quatro a seis meses de idade gestacional corrigida. O grupo controle permanecia em aleitamento materno exclusivo sem suplementação. Após acompanhamento mensal, foi feita avaliação do desenvolvimento por meio da Escala de Bayley III. Na comparação do desenvolvimento pela Escala de Bayley III entre os grupos intervenção e controle, não houve diferença estatística significativa nos domínios estudados: motor, cognitivo e linguagem. Porém, os valores dos escores foram sempre maiores no grupo intervenção do que no grupo controle nos três domínios. O atraso de desenvolvimento se distribuiu de forma similar nos grupos: sete casos (28%) no grupo intervenção e nove (33,3%) no grupo controle. Os resultados não mostraram associação entre suplementação multicomponente pós‐alta e desenvolvimento dos lactentes analisados pela Escala de Bayley III." @default.
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- W4255176568 date "2016-03-01" @default.
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- W4255176568 title "Breast milk supplementation and preterm infant development after hospital discharge: a randomized clinical trial" @default.
- W4255176568 doi "https://doi.org/10.1016/j.jpedp.2015.09.012" @default.
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