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- W4255186786 abstract "This chapter discusses the adverse effects of drugs of abuse. Neuropsychiatric complications have been reported with methylenedioxymethamphetamine (MDMA). Amphetamines are associated with most adverse effects that are more severe than the effects of MDMA or cocaine. Amphetamine users experience severe sleep disturbances and severe problems with paranoia, depression, anxiety, and irritability. Acute hypoglycemia after MDMA abuse has also been reported. Aplastic anemia could also be an idiosyncratic reaction to MDMA or possibly related to contaminants. Reports of rhabdomyolysis with raised creatine kinase activity after MDMA have been accounted. However, creatine kinase activity may not reliably predict the extent of muscle damage and the risk of acute renal failure. Adulterant benzocaine cut into the methamphetamine may cause methemoglobinemia. Myocardial infarction can occur after illicit or therapeutic cocaine exposure. Mechanism such as thrombosis with or without vasospasm may underlie cocaine-related coronary occlusion. Aortic dissection can also occur after cocaine use. With raised arterial blood pressure and increased afterload secondary to peripheral vasoconstriction, stress in the wall of the aorta can undergo a steep rise, predisposing to dissection." @default.
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- W4255186786 date "1999-01-01" @default.
- W4255186786 modified "2023-09-23" @default.
- W4255186786 title "Drugs of abuse" @default.
- W4255186786 doi "https://doi.org/10.1016/s0378-6080(99)80009-9" @default.
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