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- W4255194054 abstract "This is a comment to the Letter-to-the-Editor of Jon Pritchard et al in regard to Improved survival outcome for hepatoblastoma based on an optimal chemotherapeutic regimen—A report from the study group for pediatric solid malignant tumors in the Kyushu area, Japan. First question: What was the chemotherapy regimen used to treat those designed “Group A” before 1991? As mentioned in the Materials and Methods, all patients in group A were treated based solely on institutional choice. Those regimens varied greatly such as the combination of vincristine, actnomycin D, and cyclophosphamide except for cisplatin and Adriamycin. Second question: What proportion of the patients underwent transarterial chemoembolization (TACE) of their primary tumor? The TACE was administered based solely on institutional choice, and the timing and dose of TACE varied greatly. Therefore, no assessment of TACE was performed in this study. Third question: Why do Suita and colleagues advocate “strong multidrug chemotherapy” when, after resection of the primary tumor, the surgical margins are microscopically positive? The chemotherapy of cisplatin and Adriamycin (standard chemotherapy) is the most sensitive to the hepatoblastoma. However, the small portion of all heaptoblastomas or intratumors is resistant against the standard chemotherapy. We think that microscopically residual cells of the surgical margins after the several courses of the standard chemotherapy may be resistant against such chemotherapy. Fourth question: There appears to be some confusion about the definition of low serum AFP levels (100 μg/L). In this study, there was only 1 case with serum level less than 100 μg/L. This patient was a 5-year-old girl with PRETEXT III and alive with no disease." @default.
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- W4255194054 date "2004-11-01" @default.
- W4255194054 modified "2023-10-18" @default.
- W4255194054 title "Reply" @default.
- W4255194054 doi "https://doi.org/10.1016/j.jpedsurg.2004.07.057" @default.
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