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- W4255207718 abstract "Liposomal formulations are frequently used for oral, topical, or parenteral drug administration. However, liposome manufacturing and industrial scale-up remains a challenge, in particular if it comes to the preparation of liposome populations with a homogenous size distribution. Therefore, extrusion through filter membranes with defined pore size is traditionally used during the preparation of small unilamellar liposomes. Microfluidics is considered to be an alternative manufacturing method. Lipids, solvents and excipients are thereby passively mixed using a microfluidics device. While the microfluidic approach is highly scalable, most of the traditional liposome preparation protocols rely on extrusion. It was therefore the aim of the present study to compare liposomal formulations with identical composition, which were prepared using either extrusion or microfluidics protocols. Liposomal formulations produced by both methods were analyzed using dynamic light scattering (DLS) to compare size, polydispersity, and ζ-potential. Our results indicate significant differences between liposomal preparations obtained using the two manufacturing methods. We conclude that the two preparation methods should not be used interchangeably.<br>" @default.
- W4255207718 created "2022-05-12" @default.
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- W4255207718 date "2021-05-19" @default.
- W4255207718 modified "2023-10-14" @default.
- W4255207718 title "Manufacturing of Liposomes: A Direct Comparison of Extrusion and Microfluidics Protocols" @default.
- W4255207718 doi "https://doi.org/10.26434/chemrxiv.14604921" @default.
- W4255207718 hasPublicationYear "2021" @default.
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