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- W4255289328 abstract "Publisher SummaryThis chapter focuses on Filoviridae family whose two member genuses are Marburgvirus and Ebolavirus. The virions of this family are bacilliform in shape, but particles can also appear as branched, circular, U, or 6-shaped, and in long filamentous forms. They vary greatly in length but show a uniform width of about 80 nm, and their peak infectivity has been associated with particles of about 665 nm in the case of marburgviruses and about 805 nm in the case of ebolaviruses. The virions are composed of a central core formed by a nucleocapsid or ribonucleoprotein (RNP) complex, and surrounded by a lipid envelope derived from the host-cell plasma membrane. The filovirus RNP complexes are composed of a genomic RNA molecule and four virion-associated structural proteins, which include NP (nucleoprotein), VP35 (RNA-dependent RNA polymerase cofactor), VP30 (transcriptional activator), and L (RNA-dependent RNA polymerase). The viral envelope is derived from host cell membranes and is considered to have a lipid composition similar to that of the host-cell plasma membrane. The spike glycoproteins of filoviruses are highly glycosylated with N-linked glycans of the complex, hybrid, and oligomannosidic type, and O-linked glycans of the neutral mucin type. Filovirus genomes demonstrate a significantly high complementarity at their very ends and the genes are flanked by conserved transcriptional initiation and termination (polyadenylation) sites. Most genes are separated by nonconserved intergenic sequences, but some genes overlap. Most of these overlaps are extremely short and are limited to the highly conserved pentamer. Filoviruses are endemic in Central Africa in an area approximately between the 10th parallel north and south of the Equator as indicated by the locations of known outbreaks, and in the Philippines. They are the only mononegaviruses that cause viral hemorrhagic fevers in primates." @default.
- W4255289328 created "2022-05-12" @default.
- W4255289328 date "2012-01-01" @default.
- W4255289328 modified "2023-09-26" @default.
- W4255289328 title "Filoviridae" @default.
- W4255289328 doi "https://doi.org/10.1016/b978-0-12-384684-6.00055-0" @default.
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