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- W4255335108 abstract "The aim of this study was to elucidate the renal lesions of leptin receptor-deficient medaka showing hyperglycemia and hypoinsulinemia and to evaluate the usefulness of the medaka as a model of diabetic nephropathy. Leptin receptor-deficient medaka at 20 and 30 weeks of age showed hyperglycemia and hypoinsulinemia; they also showed a higher level of plasma creatinine than the control medaka. Histopathologically, dilation of glomerular capillary lumina and of afferent/efferent arterioles was observed in leptin receptor-deficient medaka at 20 weeks of age, and then glomerular enlargement with cell proliferation and matrix expansion, formation of fibrin cap-like lesions, glomerular atrophy with Bowman's capsule dilation, and renal tubule dilation were observed at 30 weeks of age. These histopathological characteristics of leptin receptor-deficient medaka were similar to the characteristics of kidney lesions of human and rodent models of type II diabetes mellitus, making leptin receptor-deficient medaka a useful model of diabetic nephropathy." @default.
- W4255335108 created "2022-05-12" @default.
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- W4255335108 date "2019-01-01" @default.
- W4255335108 modified "2023-10-18" @default.
- W4255335108 title "Renal lesions in leptin receptor-deficient medaka (<i>Oryzias latipes</i>)" @default.
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- W4255335108 doi "https://doi.org/10.1293/tox.2019-0021" @default.
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