Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255339962> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4255339962 endingPage "120" @default.
- W4255339962 startingPage "109" @default.
- W4255339962 abstract "Presynaptic inhibition of the extensor (quadriceps, QUAD) monosynaptic reflex (MSR) in unanaesthetized decerebrate cats was antagonized by imipramine hydrochloride (2–5 mg/kg), 5-hydroxytryptophan (75 mg/kg) and a specific 5-hydroxytryptamine (5-HT) neuronal uptake blocker, fluoxetine hydrochloride (Lilly 110140, 0.25–6 mg/kg). These effects of imipramine and fluoxetine were partially reversed by the 5-HT antagonist, cyproheptadine hydrochloride (5 mg/kg), and completely reversed by the application of a thoracic cold block which prevents supraspinal inputs to the caudal spinal cord. Imipramine, however, failed to antagonize this inhibition in animals pretreated with eitherdl-p-chlorophenylalanine (p-CPA, 300 mg/kg i.p. for 2 consecutive days) ordl-α-methyl-p-tyrosine methyl ester hydrochloride (α-MPT, 125 mg/kg i.p. 16 and 4 h prior to the experiment). Cyproheptadine (2.5–5 mg/kg), phenoxybenzamine hydrochloride (2.5–5 mg/kg) and a cold block enhanced the inhibition of this extensor MSR but a cold block failed to alter the inhibition in animals pretreated withp-CPA or α-MPT. Presynaptic inhibition of the flexor (posterior biceps-semitendinosus, PBST) MSR was however not blocked by imipramine, fluoxetine or a cold block nor enhanced by cyproheptadine or phenoxybenzamine. The effects of the drugs tested and a cold block on the excitability of the QUAD group Ia afferents were reciprocal to those on the MSR during presynaptic inhibition. The results of this study indicate that descending tonically active systems (1) involving 5-HT and noradrenaline, antagonize presynaptic inhibition of the QUAD but not the PBST-MSR, (2) decrease the excitability of the QUAD Ia afferents and (3) increase the excitability of QUAD motoneurones." @default.
- W4255339962 created "2022-05-12" @default.
- W4255339962 creator A5025828862 @default.
- W4255339962 creator A5057302729 @default.
- W4255339962 date "1977-03-01" @default.
- W4255339962 modified "2023-10-02" @default.
- W4255339962 title "Tonic inhibitory influence of a supraspinal monoaminergic system on presynaptic inhibition of an extensor monosynaptic reflex" @default.
- W4255339962 cites W1969954889 @default.
- W4255339962 cites W1995553997 @default.
- W4255339962 cites W1999318952 @default.
- W4255339962 cites W2005631666 @default.
- W4255339962 cites W2010226712 @default.
- W4255339962 cites W2013231063 @default.
- W4255339962 cites W2019842906 @default.
- W4255339962 cites W2055007251 @default.
- W4255339962 cites W2067319613 @default.
- W4255339962 cites W2077194045 @default.
- W4255339962 cites W2087517159 @default.
- W4255339962 cites W2152143669 @default.
- W4255339962 cites W2228666107 @default.
- W4255339962 cites W3186732934 @default.
- W4255339962 doi "https://doi.org/10.1016/0006-8993(77)90867-8" @default.
- W4255339962 hasPublicationYear "1977" @default.
- W4255339962 type Work @default.
- W4255339962 citedByCount "12" @default.
- W4255339962 crossrefType "journal-article" @default.
- W4255339962 hasAuthorship W4255339962A5025828862 @default.
- W4255339962 hasAuthorship W4255339962A5057302729 @default.
- W4255339962 hasConcept C126322002 @default.
- W4255339962 hasConcept C134018914 @default.
- W4255339962 hasConcept C142724271 @default.
- W4255339962 hasConcept C170493617 @default.
- W4255339962 hasConcept C17077164 @default.
- W4255339962 hasConcept C185592680 @default.
- W4255339962 hasConcept C204787440 @default.
- W4255339962 hasConcept C2775864247 @default.
- W4255339962 hasConcept C2776885963 @default.
- W4255339962 hasConcept C2778206117 @default.
- W4255339962 hasConcept C2779145073 @default.
- W4255339962 hasConcept C2780668150 @default.
- W4255339962 hasConcept C2780831388 @default.
- W4255339962 hasConcept C2781005078 @default.
- W4255339962 hasConcept C42219234 @default.
- W4255339962 hasConcept C55493867 @default.
- W4255339962 hasConcept C71924100 @default.
- W4255339962 hasConcept C83974742 @default.
- W4255339962 hasConcept C98274493 @default.
- W4255339962 hasConceptScore W4255339962C126322002 @default.
- W4255339962 hasConceptScore W4255339962C134018914 @default.
- W4255339962 hasConceptScore W4255339962C142724271 @default.
- W4255339962 hasConceptScore W4255339962C170493617 @default.
- W4255339962 hasConceptScore W4255339962C17077164 @default.
- W4255339962 hasConceptScore W4255339962C185592680 @default.
- W4255339962 hasConceptScore W4255339962C204787440 @default.
- W4255339962 hasConceptScore W4255339962C2775864247 @default.
- W4255339962 hasConceptScore W4255339962C2776885963 @default.
- W4255339962 hasConceptScore W4255339962C2778206117 @default.
- W4255339962 hasConceptScore W4255339962C2779145073 @default.
- W4255339962 hasConceptScore W4255339962C2780668150 @default.
- W4255339962 hasConceptScore W4255339962C2780831388 @default.
- W4255339962 hasConceptScore W4255339962C2781005078 @default.
- W4255339962 hasConceptScore W4255339962C42219234 @default.
- W4255339962 hasConceptScore W4255339962C55493867 @default.
- W4255339962 hasConceptScore W4255339962C71924100 @default.
- W4255339962 hasConceptScore W4255339962C83974742 @default.
- W4255339962 hasConceptScore W4255339962C98274493 @default.
- W4255339962 hasIssue "1" @default.
- W4255339962 hasLocation W42553399621 @default.
- W4255339962 hasOpenAccess W4255339962 @default.
- W4255339962 hasPrimaryLocation W42553399621 @default.
- W4255339962 hasRelatedWork W2027411819 @default.
- W4255339962 hasRelatedWork W2036082219 @default.
- W4255339962 hasRelatedWork W2037109444 @default.
- W4255339962 hasRelatedWork W2054184534 @default.
- W4255339962 hasRelatedWork W2060730794 @default.
- W4255339962 hasRelatedWork W2081245175 @default.
- W4255339962 hasRelatedWork W2105500940 @default.
- W4255339962 hasRelatedWork W2107899720 @default.
- W4255339962 hasRelatedWork W2160769306 @default.
- W4255339962 hasRelatedWork W4241062279 @default.
- W4255339962 hasVolume "124" @default.
- W4255339962 isParatext "false" @default.
- W4255339962 isRetracted "false" @default.
- W4255339962 workType "article" @default.