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- W4255351067 abstract "Abstract GPCR proteins belong to diverse families of proteins that are defined at multiple hierarchical levels. Inspecting relationships between GPCR proteins on the hierarchical structure is important, since characteristics of the protein can be inferred from proteins in similar hierarchical information. However, modeling of GPCR families has been performed separately at each level. Relationships between GPCR proteins are ignored in these approaches as they process the information in the proteins with several disconnected models. In this study, we propose a deep learning model to simultaneously learn representations of GPCR family hierarchy from the protein sequences with a unified single model. Novel loss term based on metric learning is introduced to incorporate hierarchical relations between proteins. We tested our approach using a public GPCR sequence dataset. Metric distances in the deep feature space corresponded to the hierarchical family relation between GPCR proteins. Furthermore, we demonstrated that further downstream tasks, like phylogenetic reconstruction and motif discovery, are feasible in the constructed embedding space. These results show that hierarchical relations between sequences were successfully captured in both of technical and biological aspects." @default.
- W4255351067 created "2022-05-12" @default.
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- W4255351067 date "2021-01-29" @default.
- W4255351067 modified "2023-09-28" @default.
- W4255351067 title "Deep Hierarchical Embedding for Simultaneous Modeling of GPCR Proteins in a Unified Metric Space" @default.
- W4255351067 doi "https://doi.org/10.21203/rs.3.rs-154212/v1" @default.
- W4255351067 hasPublicationYear "2021" @default.
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