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- W4255351805 abstract "Individuals with higher education have a lower risk of developing cognitive decline or Alzheimer's disease dementia at late age, suggesting that education is associated with enhanced reserve in late-life that helps maintaining memory and other cognitive abilities. Yet, an unresolved question is which functional brain mechanisms underlie such protective effects of education. We and others have previously shown that intrinsic connectivity of fronto-parietal control network (FPCN) hubs is enhanced in individuals with higher education and IQ. Such intrinsic connectivity is thought to reflect the FPCNs’ ability to exert control on other functional networks during cognitive demands, thereby increasing efficient information processing. Here, we tested the hypothesis that protective effects of education on memory in aging are associated with higher cross-network FPCN-connectivity and thus more efficient network processing during a memory task. Face-name memory task-fMRI was applied in 26 healthy elderly participants. Using beta-series correlation, we assessed task-related connectivity during successful memory performance between a set of 264 ROIs covering the whole brain. Subsequently, we computed global efficiency within ten major functional networks using graph-theory. Lastly, we assessed the degree of FPCN connectivity to each of the remaining nine functional networks to assess FPCN cross-network coupling. Using structural equation modeling we tested whether greater education predicted higher network efficiency via greater FPCN-cross network coupling and whether higher network efficiency predicted better memory performance. Higher education significantly (p<0.05) predicted higher global efficiency in the default-mode (DMN) and dorsal attention network (DAN), during successful memory encoding and recall (see Fig. 1), which in turn predicted better memory performance, with correction for multiple testing. The associations between education and global efficiency of the DMN and DAN were mediated by FPCN-connectivity to both of these networks (see Fig. 2 for structural equation model)." @default.
- W4255351805 created "2022-05-12" @default.
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- W4255351805 date "2017-07-01" @default.
- W4255351805 modified "2023-10-16" @default.
- W4255351805 title "[P1-431]: CROSS-NETWORK COUPLING OF THE FRONTO-PARIETAL CONTROL NETWORK DURING MEMORY PERFORMANCE SUPPORTS PROTECTIVE EFFECTS OF EDUCATION IN AGING" @default.
- W4255351805 doi "https://doi.org/10.1016/j.jalz.2017.06.447" @default.
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