Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255357025> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4255357025 endingPage "216" @default.
- W4255357025 startingPage "215" @default.
- W4255357025 abstract "Spatial and non-spatial learning of mice with an incorporated antisense RNA complementary to a fragment of cDNA coding for the glucocorticoid receptor (GR) were evaluated in allocentric and egocentric radial maze and water maze tasks, and in spontaneous object recognition and sensorimotor learning paradigms. Mice with impaired GR function did not acquire two maze paradigms based on allocentric spatial navigation, radial maze non-matching to position and water maze spatial discrimination learning. Comparison of performance in spaced and massed trials indicated that this may be due to a general inability to store information into allocentric reference memory or in retrieval processes. However, both groups of animals learned the rules of an egocentric radial maze task at similar rates and there was no difference in their ability to recognise objects once animals had equal opportunity to explore the sample objects. Sensorimotor performance was impaired in transgenic animals, but it is suggested that this is due to non-specific factors rather than to disrupted sensorimotor learning per se. These results are consistent with a disruption of hippocampal function. Histological examination of the hippocampus revealed no obvious structural abnormalities in transgenic animals. Therefore, the data suggest that functional underactivity of GRs at the level of the hippocampus induces a deficit in allocentric navigation while sparing egocentric navigation and object recognition." @default.
- W4255357025 created "2022-05-12" @default.
- W4255357025 date "2003-03-01" @default.
- W4255357025 modified "2023-09-30" @default.
- W4255357025 title "Author Index" @default.
- W4255357025 doi "https://doi.org/10.1016/s0166-4328(03)00054-8" @default.
- W4255357025 hasPublicationYear "2003" @default.
- W4255357025 type Work @default.
- W4255357025 citedByCount "0" @default.
- W4255357025 crossrefType "journal-article" @default.
- W4255357025 hasConcept C12515866 @default.
- W4255357025 hasConcept C13260007 @default.
- W4255357025 hasConcept C148762608 @default.
- W4255357025 hasConcept C15744967 @default.
- W4255357025 hasConcept C169760540 @default.
- W4255357025 hasConcept C169900460 @default.
- W4255357025 hasConcept C21963081 @default.
- W4255357025 hasConcept C2781161787 @default.
- W4255357025 hasConcept C2985665543 @default.
- W4255357025 hasConcept C43729271 @default.
- W4255357025 hasConcept C44752575 @default.
- W4255357025 hasConceptScore W4255357025C12515866 @default.
- W4255357025 hasConceptScore W4255357025C13260007 @default.
- W4255357025 hasConceptScore W4255357025C148762608 @default.
- W4255357025 hasConceptScore W4255357025C15744967 @default.
- W4255357025 hasConceptScore W4255357025C169760540 @default.
- W4255357025 hasConceptScore W4255357025C169900460 @default.
- W4255357025 hasConceptScore W4255357025C21963081 @default.
- W4255357025 hasConceptScore W4255357025C2781161787 @default.
- W4255357025 hasConceptScore W4255357025C2985665543 @default.
- W4255357025 hasConceptScore W4255357025C43729271 @default.
- W4255357025 hasConceptScore W4255357025C44752575 @default.
- W4255357025 hasIssue "1-2" @default.
- W4255357025 hasLocation W42553570251 @default.
- W4255357025 hasOpenAccess W4255357025 @default.
- W4255357025 hasPrimaryLocation W42553570251 @default.
- W4255357025 hasRelatedWork W1935714934 @default.
- W4255357025 hasRelatedWork W2029439671 @default.
- W4255357025 hasRelatedWork W2031050147 @default.
- W4255357025 hasRelatedWork W2036697761 @default.
- W4255357025 hasRelatedWork W2054576088 @default.
- W4255357025 hasRelatedWork W2110906240 @default.
- W4255357025 hasRelatedWork W2144877080 @default.
- W4255357025 hasRelatedWork W2153719608 @default.
- W4255357025 hasRelatedWork W2381750903 @default.
- W4255357025 hasRelatedWork W2942595690 @default.
- W4255357025 hasVolume "140" @default.
- W4255357025 isParatext "false" @default.
- W4255357025 isRetracted "false" @default.
- W4255357025 workType "article" @default.