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• W4255358539 startingPage "1182" @default.
• W4255358539 abstract "Abstract Context.—Interstitial cells of Cajal (ICCs) are pacemaker cells, which are of fundamental importance in regulating gastrointestinal motility. Recent evidence suggests that carbon monoxide is a neurotransmitter involved in neurotransmission between ICC and smooth muscle cells. Heme oxygenase-2 (HO-2) is the major physiological mechanism for the generation of carbon monoxide in the enteric nervous system. Objective.—To investigate the immunocolocalization of HO-2 and ICCs in the normal pylorus and in infantile hypertrophic pyloric stenosis (IHPS). Design.—Specimens from 18 infants with IHPS and 8 control specimens were examined using double-immunostaining with c-Kit and HO-2 antibodies. The immunolocalization was detected with the help of confocal laser scanning microscopy. Results.—Abundant HO-2 immunoreactivity was found in ICCs in the smooth muscle layer of normal pylorus. There was a decrease in the number of ICCs and lack of HO-2 immunoreactivity in ICCs in IHPS. Conclusions.—The results of the present study provide the first evidence for the presence of HO-2 in ICCs in the normal human pylorus. The lack of ICCs and HO-2 in IHPS suggests impaired intracellular communication between ICCs and smooth muscle cells, contributing to motility dysfunction in IHPS." @default.
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• W4255358539 date "2003-09-01" @default.
• W4255358539 modified "2023-09-25" @default.
• W4255358539 title "Distribution of Heme Oxygenase-2 in Nerves and Interstitial Cells of Cajal in the Normal Pylorus and in Infantile Hypertrophic Pyloric Stenosis" @default.
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• W4255358539 doi "https://doi.org/10.5858/2003-127-1182-dohoin" @default.
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