Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255376498> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4255376498 abstract "Diclofenac (DCLF) is a potent inhibitor of prostaglandin synthesis and an established antipyretic and analgesic agent. It also has a nephrotoxic profile caused by generation of reactive oxygen species and enhanced apoptotic DNA fragmentation. The specific goals of this investigation were to determine: (i) sensitivity of hyperglycemic mice to nephrotoxic doses of DCLF, (ii) whether hyperglycemia modulates genomic DNA-fragmenting potency of DCLF in kidney, (iii) whether hyperglycemia would increase DCF-induced oxidative stress in kidney and (iv) whether hyperglycemia can alter apoptotic and necrotic death of kidney cells. Male ICR CD-I mice were divided into normal and diabetic groups. Diabetes was induced by administering 100 mg/kg streptozotocin. Both normal and diabetic groups were divided into sub-groups on basis of nephrotoxic doses of DCLF i.e., 100 and 200 mg/kg i.p. The mice were sacrificed after 24-hrs and determined blood urea nitrogen (BUN), lipid peroxidation level and caspase-activated DNAase-mediated genomic DNA fragmentation. In addition, kidney tissues were examined histopathologically and checked for DNA damage. The results obtained showed that DCLF is a potent nephrotoxic agent as it increases BUN and powerfully induces oxidative stress depicted by significant increase in malandialdehyde (MDA) level which lead to massive DNA fragmentation coupled with apoptotic and necrotic cell deaths in both diabetic and non-diabetic groups in vivo. In addition, data have indicated that DCF causes greater nephrotoxicity in diabetics as compared to non-diabetics as shown by higher values of BUN, LPG and genomic DNA fragmentation." @default.
- W4255376498 created "2022-05-12" @default.
- W4255376498 date "2011-01-01" @default.
- W4255376498 modified "2023-09-28" @default.
- W4255376498 doi "https://doi.org/10.21065/1925-7430.129" @default.
- W4255376498 hasPublicationYear "2011" @default.
- W4255376498 type Work @default.
- W4255376498 citedByCount "0" @default.
- W4255376498 crossrefType "journal-issue" @default.
- W4255376498 hasBestOaLocation W42553764981 @default.
- W4255376498 hasConcept C126189478 @default.
- W4255376498 hasConcept C126322002 @default.
- W4255376498 hasConcept C134018914 @default.
- W4255376498 hasConcept C143425029 @default.
- W4255376498 hasConcept C150903083 @default.
- W4255376498 hasConcept C185592680 @default.
- W4255376498 hasConcept C18903297 @default.
- W4255376498 hasConcept C190283241 @default.
- W4255376498 hasConcept C191015642 @default.
- W4255376498 hasConcept C207001950 @default.
- W4255376498 hasConcept C2776151105 @default.
- W4255376498 hasConcept C2778176769 @default.
- W4255376498 hasConcept C2779280383 @default.
- W4255376498 hasConcept C2780091579 @default.
- W4255376498 hasConcept C2780829032 @default.
- W4255376498 hasConcept C31573885 @default.
- W4255376498 hasConcept C43759708 @default.
- W4255376498 hasConcept C552990157 @default.
- W4255376498 hasConcept C55493867 @default.
- W4255376498 hasConcept C555293320 @default.
- W4255376498 hasConcept C71924100 @default.
- W4255376498 hasConcept C86803240 @default.
- W4255376498 hasConcept C98274493 @default.
- W4255376498 hasConceptScore W4255376498C126189478 @default.
- W4255376498 hasConceptScore W4255376498C126322002 @default.
- W4255376498 hasConceptScore W4255376498C134018914 @default.
- W4255376498 hasConceptScore W4255376498C143425029 @default.
- W4255376498 hasConceptScore W4255376498C150903083 @default.
- W4255376498 hasConceptScore W4255376498C185592680 @default.
- W4255376498 hasConceptScore W4255376498C18903297 @default.
- W4255376498 hasConceptScore W4255376498C190283241 @default.
- W4255376498 hasConceptScore W4255376498C191015642 @default.
- W4255376498 hasConceptScore W4255376498C207001950 @default.
- W4255376498 hasConceptScore W4255376498C2776151105 @default.
- W4255376498 hasConceptScore W4255376498C2778176769 @default.
- W4255376498 hasConceptScore W4255376498C2779280383 @default.
- W4255376498 hasConceptScore W4255376498C2780091579 @default.
- W4255376498 hasConceptScore W4255376498C2780829032 @default.
- W4255376498 hasConceptScore W4255376498C31573885 @default.
- W4255376498 hasConceptScore W4255376498C43759708 @default.
- W4255376498 hasConceptScore W4255376498C552990157 @default.
- W4255376498 hasConceptScore W4255376498C55493867 @default.
- W4255376498 hasConceptScore W4255376498C555293320 @default.
- W4255376498 hasConceptScore W4255376498C71924100 @default.
- W4255376498 hasConceptScore W4255376498C86803240 @default.
- W4255376498 hasConceptScore W4255376498C98274493 @default.
- W4255376498 hasLocation W42553764981 @default.
- W4255376498 hasOpenAccess W4255376498 @default.
- W4255376498 hasPrimaryLocation W42553764981 @default.
- W4255376498 hasRelatedWork W1978041418 @default.
- W4255376498 hasRelatedWork W2022297125 @default.
- W4255376498 hasRelatedWork W2036757621 @default.
- W4255376498 hasRelatedWork W2117519097 @default.
- W4255376498 hasRelatedWork W2161791039 @default.
- W4255376498 hasRelatedWork W2186559937 @default.
- W4255376498 hasRelatedWork W2272046160 @default.
- W4255376498 hasRelatedWork W2400445066 @default.
- W4255376498 hasRelatedWork W4237231359 @default.
- W4255376498 hasRelatedWork W2042893290 @default.
- W4255376498 hasVolume "1" @default.
- W4255376498 isParatext "false" @default.
- W4255376498 isRetracted "false" @default.
- W4255376498 workType "paratext" @default.