Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255386914> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4255386914 endingPage "v" @default.
- W4255386914 startingPage "iii" @default.
- W4255386914 abstract "Polar residues are capable of mediating the association of membrane-embedded helices through the formation of side-chain/side-chain inter-helical hydrogen bonds. However, the extent to which native van der Waals packing of the residues surrounding the polar locus can enhance, or interfere with, the interaction of polar residues has not yet been studied. We examined the propensities of four polar residues (aspartic acid, asparagine, glutamic acid, and glutamine) to promote self-association of transmembrane (TM) domains in several biologically derived sequence environments, including (i) four naturally occurring TM domains that contain a Glu or Gln residue (Tnf5/CD40 ligand, C79a/Ig-α, C79b/Ig-β, and Fut3/α-fucosyltransferase); and (ii) variants of bacteriophage M13 major coat protein TM segment with Asp and Asn at interfacial and non-interfacial positions. Self-association was quantified by the TOXCAT assay, which measures TM helix self-oligomerization in the Escherichia coli inner membrane. While an appropriately placed polar residue was found in several cases to significantly stabilize TM helix–helix interactions through the formation of an interhelical hydrogen bond, in other cases the strongly polar residues did not enhance the association of the two helices. Overall, these results suggest that an innate structural mechanism may operate to control non-specific association of membrane-embedded polar residues." @default.
- W4255386914 created "2022-05-12" @default.
- W4255386914 date "2003-08-01" @default.
- W4255386914 modified "2023-09-26" @default.
- W4255386914 title "Contents list" @default.
- W4255386914 doi "https://doi.org/10.1016/s0022-2836(03)00909-4" @default.
- W4255386914 hasPublicationYear "2003" @default.
- W4255386914 type Work @default.
- W4255386914 citedByCount "0" @default.
- W4255386914 crossrefType "journal-article" @default.
- W4255386914 hasConcept C112887158 @default.
- W4255386914 hasConcept C118892022 @default.
- W4255386914 hasConcept C121332964 @default.
- W4255386914 hasConcept C1276947 @default.
- W4255386914 hasConcept C170493617 @default.
- W4255386914 hasConcept C178790620 @default.
- W4255386914 hasConcept C185592680 @default.
- W4255386914 hasConcept C18903297 @default.
- W4255386914 hasConcept C204921945 @default.
- W4255386914 hasConcept C24530287 @default.
- W4255386914 hasConcept C2775895851 @default.
- W4255386914 hasConcept C2778460671 @default.
- W4255386914 hasConcept C2778530040 @default.
- W4255386914 hasConcept C2779349466 @default.
- W4255386914 hasConcept C2779965526 @default.
- W4255386914 hasConcept C2781208047 @default.
- W4255386914 hasConcept C2781338088 @default.
- W4255386914 hasConcept C29705727 @default.
- W4255386914 hasConcept C32909587 @default.
- W4255386914 hasConcept C515207424 @default.
- W4255386914 hasConcept C521977710 @default.
- W4255386914 hasConcept C55493867 @default.
- W4255386914 hasConcept C71240020 @default.
- W4255386914 hasConcept C8010536 @default.
- W4255386914 hasConcept C86803240 @default.
- W4255386914 hasConceptScore W4255386914C112887158 @default.
- W4255386914 hasConceptScore W4255386914C118892022 @default.
- W4255386914 hasConceptScore W4255386914C121332964 @default.
- W4255386914 hasConceptScore W4255386914C1276947 @default.
- W4255386914 hasConceptScore W4255386914C170493617 @default.
- W4255386914 hasConceptScore W4255386914C178790620 @default.
- W4255386914 hasConceptScore W4255386914C185592680 @default.
- W4255386914 hasConceptScore W4255386914C18903297 @default.
- W4255386914 hasConceptScore W4255386914C204921945 @default.
- W4255386914 hasConceptScore W4255386914C24530287 @default.
- W4255386914 hasConceptScore W4255386914C2775895851 @default.
- W4255386914 hasConceptScore W4255386914C2778460671 @default.
- W4255386914 hasConceptScore W4255386914C2778530040 @default.
- W4255386914 hasConceptScore W4255386914C2779349466 @default.
- W4255386914 hasConceptScore W4255386914C2779965526 @default.
- W4255386914 hasConceptScore W4255386914C2781208047 @default.
- W4255386914 hasConceptScore W4255386914C2781338088 @default.
- W4255386914 hasConceptScore W4255386914C29705727 @default.
- W4255386914 hasConceptScore W4255386914C32909587 @default.
- W4255386914 hasConceptScore W4255386914C515207424 @default.
- W4255386914 hasConceptScore W4255386914C521977710 @default.
- W4255386914 hasConceptScore W4255386914C55493867 @default.
- W4255386914 hasConceptScore W4255386914C71240020 @default.
- W4255386914 hasConceptScore W4255386914C8010536 @default.
- W4255386914 hasConceptScore W4255386914C86803240 @default.
- W4255386914 hasIssue "2" @default.
- W4255386914 hasLocation W42553869141 @default.
- W4255386914 hasOpenAccess W4255386914 @default.
- W4255386914 hasPrimaryLocation W42553869141 @default.
- W4255386914 hasRelatedWork W1910818452 @default.
- W4255386914 hasRelatedWork W1973367065 @default.
- W4255386914 hasRelatedWork W2007473167 @default.
- W4255386914 hasRelatedWork W2076072268 @default.
- W4255386914 hasRelatedWork W2089878534 @default.
- W4255386914 hasRelatedWork W2093405432 @default.
- W4255386914 hasRelatedWork W2134880328 @default.
- W4255386914 hasRelatedWork W2171058912 @default.
- W4255386914 hasRelatedWork W2583599611 @default.
- W4255386914 hasRelatedWork W4319290834 @default.
- W4255386914 hasVolume "331" @default.
- W4255386914 isParatext "false" @default.
- W4255386914 isRetracted "false" @default.
- W4255386914 workType "article" @default.