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• W4255405909 abstract "Abstract Background The bovine upper respiratory tract (URT) microbiome includes opportunistic pathogens that cause respiratory disease and stress associated with maternal separation and transportation contributes to the severity of this respiratory disease. Stress is known to alter the gut microbiome but little is known regarding the effect of stress on the URT microbiota. This study used six-month old suckling beef calves to investigate whether maternal separation (weaned), by itself or combined with transportation (weaned + transport), altered the URT microbiome and host immune responses to resident opportunistic pathogens. Results Taxonomic and functional composition of the URT microbiome in suckling and weaned beef calves did not change significantly when serially sampled over a one-month period. Subtle temporal changes in the URT microbiome composition were observed in weaned + transport calves. Total bacterial density was lower ( p <0.05) on day 4 post-weaning in both the weaned and weaned + transport groups when compared to suckling calves. In addition, significant ( p <0.05) temporal changes in the density of the opportunistic pathogens, M. haemolytica and P. multocida , were observed independent of treatment but these changes did not correlate with significantly increased ( p <0.05) serum antibody responses to both of these bacteria in the weaned and weaned + transport groups. Weaning, by itself and in combination with transportation, had significant ( p <0.05) short- (2 to 8 days post-weaning) and long-term (28 days post-weaning) effects on the expression of adrenergic receptor genes in blood leukocytes when compared to age-matched suckling beef calves. Conclusions Maternal separation (weaning) and transportation has minor effects on the taxonomic and functional composition of the URT microbiome and temporal changes in the density of opportunistic pathogen residing in the URT did not correlate with the significant changes in immune responses to these bacteria. Significant changes in adrenergic receptor expression in blood leukocytes following weaning, with or without transportation, suggests altered neuroimmune regulation should be further investigated as a mechanism by which stress can alter host-microbiome interactions in the URT." @default.
• W4255405909 created "2022-05-12" @default.
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• W4255405909 date "2021-03-02" @default.
• W4255405909 modified "2023-10-18" @default.
• W4255405909 title "Effect of Maternal Separation and Transportation Stress on the Bovine Upper Respiratory Tract Microbiome and the Immune Response to Resident Opportunistic Pathogens" @default.
• W4255405909 doi "https://doi.org/10.21203/rs.3.rs-252972/v1" @default.
• W4255405909 hasPublicationYear "2021" @default.
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